Description

Benzimidazole, 2-[(Methylnitrosamino)Methyl]- (7Ci) CAS NO 90558-63-7 is a specialized nitrosamine derivative of the benzimidazole class, a structure of significant interest in advanced chemical research and development. This compound is valued for its role as a critical synthetic intermediate and reference standard in the study of nitrosamine chemistry and its implications. It is primarily utilized by research institutions, analytical laboratories, and pharmaceutical development teams engaged in impurity profiling, method development, and investigative toxicology. Our supply is characterized by stringent quality control to ensure consistency and reliability for sensitive applications.

Application

• Pharmaceutical Impurity Reference Standard: Critical for the identification, quantification, and method validation of potentially genotoxic nitrosamine impurities (NTIs) in active pharmaceutical ingredients (APIs) and drug products, supporting compliance with global regulatory standards (e.g., FDA, EMA).
• Analytical Research & Method Development: Serves as a key analyte in developing and calibrating advanced analytical techniques such as LC-MS/MS, GC-MS, and HPLC for trace-level detection of nitrosamine compounds.
• Toxicological and Metabolic Studies: Used in academic and industrial research to investigate the formation, metabolism, and carcinogenic mechanisms of nitrosamine derivatives.
• Chemical Synthesis Intermediate: Employed in specialized organic synthesis for constructing complex molecules containing the benzimidazole-nitrosamine motif for research purposes.
• Quality Control & Assurance: Provides a certified reference material for internal quality control laboratories in the chemical and pharmaceutical industries to ensure supply chain integrity.

Basic Information

Product Name	Benzimidazole, 2-[(Methylnitrosamino)Methyl]- (7Ci)
CAS No.	90558-63-7
Molecular Formula	C9H10N4O
Molecular Weight	190.20 g/mol
Synonyms	2-[(Methylnitrosamino)methyl]-1H-benzimidazole; N-Methyl-N-nitroso-1H-benzimidazol-2-ylmethanamine; MNBZA; Nitrosamine Derivative of Benzimidazole; 1H-Benzimidazole, 2-[(methylnitrosoamino)methyl]-; Research Compound 90558-63-7
EINECS	Contact for details

Quality Control

Every batch of Benzimidazole, 2-[(Methylnitrosamino)Methyl]- (7Ci) is produced and handled under a strict quality management system. The material undergoes comprehensive analytical testing, including chromatographic purity assays and structural confirmation, to ensure it meets the exacting standards required for research and analytical applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results for identity, purity, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is light-sensitive (store away from light). Keep the container tightly sealed under an inert atmosphere if prolonged storage is anticipated to minimize degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.