Description

Azithromycin n-Oxide is a key chemical intermediate and oxidative derivative of the broad-spectrum macrolide antibiotic Azithromycin. This compound is of significant interest in pharmaceutical research and development, particularly for the synthesis of novel antibiotic derivatives and for metabolic studies. It serves as a critical building block for researchers and manufacturers in the pharmaceutical and fine chemical sectors who require high-purity intermediates for advanced synthesis and analytical applications.

Application

• Pharmaceutical Intermediate: Primary use in the research and synthesis of new azithromycin analogs and related macrolide antibiotics.
• Metabolite Reference Standard: Serves as a critical analytical standard in pharmacokinetic and drug metabolism studies for azithromycin.
• Organic Synthesis Building Block: Utilized in medicinal chemistry for the preparation of complex molecules targeting bacterial infections.
• Impurity Standard: Essential for quality control laboratories to identify and quantify oxidative impurities in azithromycin active pharmaceutical ingredient (API) batches.
• Biochemical Research: Used in studies investigating the structure-activity relationships (SAR) and resistance mechanisms of macrolide antibiotics.

Basic Information

Product Name	Azithromycin n-Oxide
CAS No.	90503-06-3
Molecular Formula	C38H72N2O13
Molecular Weight	764.99 g/mol
Synonyms	9-Deoxo-9a-aza-9a-methyl-9a-homoerythromycin A N-Oxide; Azithromycin Impurity F (EP); Azithromycin N-Oxide Impurity; Azithromycin Related Compound F; 9a-Aza-9a-methyl-9-deoxo-9a-homoerythromycin A N-Oxide; (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-{[(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-on-11-yl]oxy}-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one 6-Oxide
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Quality Control

Our Azithromycin n-Oxide is produced under controlled conditions to ensure high purity and consistency, suitable for research and development applications. Each batch undergoes rigorous analytical testing, including HPLC for assay and impurity profiling, to meet stringent internal specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are kept tightly sealed in a dry environment away from direct light exposure.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0% Any individual impurity ≤ 2.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.