Description

2-Bromo-3-Nitrobenzonitrile is a versatile halogenated aromatic nitrile building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both bromo and nitro substituents on the benzonitrile core, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for applications in cross-coupling reactions and as a precursor to various heterocyclic systems.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing substituted aromatic or heteroaromatic rings.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its reactivity for structure-activity relationship (SAR) studies.
• Material Science Research: Serves as a building block for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, where its electron-withdrawing groups are beneficial.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for metal-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to form biaryl structures.
• Nucleophilic Aromatic Substitution: The nitro group activates the aromatic ring for substitution reactions, allowing for further functionalization.
• Ligand and Catalyst Development: Utilized in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Item	Details
Product Name	2-Bromo-3-Nitrobenzonitrile
CAS No.	90407-28-6
Molecular Formula	C7H3BrN2O2
Molecular Weight	227.01 g/mol
Synonyms	3-Nitro-2-bromobenzonitrile; 2-Bromo-3-nitrobenzenecarbonitrile; Benzonitrile, 2-bromo-3-nitro-; o-Bromo-m-nitrobenzonitrile; 2-Brom-3-nitro-benzonitril (German); 2-ブロモ-3-ニトロベンゾニトリル (Japanese); 2-溴-3-硝基苯甲腈 (Chinese)
EINECS	Contact for details

Quality Control

Our 2-Bromo-3-Nitrobenzonitrile is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistent performance. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.