Description

(R)-α-Methylvalinamide is a chiral, non-proteinogenic amino acid derivative of significant interest in advanced organic synthesis. Its value lies in its utility as a key chiral building block and intermediate for constructing complex, biologically active molecules. This high-purity compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly peptidomimetics and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the research and development of new drug candidates, especially for metabolic and neurological disorders.
• Peptidomimetic Synthesis: Used to introduce specific stereochemistry and structural motifs into peptide analogs to enhance stability, bioavailability, and target selectivity.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material in stereoselective reactions to create enantiomerically pure compounds.
• Biochemical Research: Employed in studies of enzyme mechanisms, receptor binding, and metabolic pathways due to its specific stereochemical configuration.
• Agrochemical Development: Potential use as an intermediate in the synthesis of chiral pesticides or herbicides where specific enantiomer activity is required.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry laboratories worldwide.

Basic Information

Product Name	(R)-α-Methylvalinamide
CAS No.	90376-98-0
Molecular Formula	C6H13NO
Molecular Weight	115.17 g/mol
Synonyms	(R)-2-Amino-3-methylbutanamide; (R)-2-Amino-3-methyl-butyramide; (R)-2-Amino-3-methylbutyric acid amide; D-α-Methylvalinamide; (R)-α-Methylvaline amide; (2R)-2-Amino-3-methylbutanamide; (R)-2-Azaniumyl-3-methylbutanamide
EINECS	Contact for details

Quality Control

Our (R)-α-Methylvalinamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to meet the exacting standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.