Description

Calcineurin CAS NO 90371-51-0 is a calcium- and calmodulin-dependent serine/threonine protein phosphatase, also known as protein phosphatase 2B (PP2B), which plays a critical role in intracellular signaling pathways. This enzyme is essential for T-cell activation and immune response regulation, making it a key target for immunosuppressive drug development and biochemical research. It is primarily utilized by pharmaceutical researchers, immunologists, and biotechnology companies engaged in drug discovery, signal transduction studies, and the development of novel therapeutic agents for autoimmune diseases and organ transplantation.

Application

• Immunosuppressant Research & Development: A primary target for developing and screening immunosuppressive drugs like Cyclosporin A and Tacrolimus (FK506).
• Biochemical & Enzymology Studies: Used in vitro to study enzyme kinetics, substrate specificity, and the mechanism of calcium/calmodulin-dependent dephosphorylation.
• Cell Signaling Pathway Analysis: Essential for investigating T-cell receptor (TCR) signaling, neuronal functions, and cardiac hypertrophy pathways.
• Pharmaceutical Reference Standard: Serves as a high-purity standard for quality control in the production of related therapeutic agents and assay development.
• Diagnostic Kit Development: Employed in the formulation of ELISA kits and other diagnostic assays for autoimmune disease profiling.
• Academic & Institutional Research: Fundamental reagent for universities and research institutes studying immunology, neurobiology, and cardiovascular biology.

Basic Information

Product Name	Calcineurin
CAS No.	90371-51-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Protein Phosphatase 2B (PP2B); Calcineurin A; Calmodulin-dependent protein phosphatase; CaM-dependent protein phosphatase; Serine/threonine-protein phosphatase 2B catalytic subunit; PPP3CA; FKBP-12-FK506 complex-associated protein; Calcineurin subunit A isoform; Calcineurin catalytic subunit
EINECS	Contact for details

Quality Control

Our Calcineurin is produced and tested under stringent quality management systems to ensure batch-to-batch consistency and high biological activity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, specific activity, and stability data. We adhere to relevant guidelines for research-grade enzymes, ensuring suitability for critical applications in pharmaceutical development and life science research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For short-term use, aliquots can be stored at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or solution
Identification (Activity)	Conforms (Phosphatase Activity Assay)
Specific Activity	≥ [Value] units/mg protein
Purity (SDS-PAGE)	≥ 90%
Protein Content	Determined by Bradford or similar method
Buffer Composition	Specified on COA
Endotoxin Level	< 1.0 EU/μg (for cell culture applications)
Biological Activity (Inhibition)	Sensitive to standard inhibitors (e.g., Cyclosporin A)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.