Description

Oxaprozin-1-Glucuronide is a major Phase II metabolite of the non-steroidal anti-inflammatory drug (NSAID) oxaprozin. This compound is of significant value for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and bioanalytical method development. It serves as a critical reference standard for scientists and quality control laboratories in the pharmaceutical and biotechnology industries.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the quantification and identification of oxaprozin metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic pathways, clearance rates, and bioavailability of oxaprozin in preclinical and clinical research.
• Bioanalytical Method Development: Used to validate and calibrate analytical methods such as HPLC, LC-MS, and LC-MS/MS for accurate metabolite detection.
• Toxicology and Safety Assessment: Aids in understanding the safety profile and potential toxicological implications of oxaprozin's metabolic products.
• Impurity Profiling: Employed in quality control to identify and quantify glucuronide-related impurities in oxaprozin active pharmaceutical ingredient (API) batches.
• Regulatory Submissions: Supports documentation for regulatory filings (e.g., FDA, EMA) requiring detailed metabolite characterization data.

Basic Information

Product Name	Oxaprozin-1-Glucuronide
CAS No.	90283-09-3
Molecular Formula	C24H25NO10
Molecular Weight	487.46 g/mol
Synonyms	Oxaprozin Glucuronide; Oxaprozin 1-O-β-Glucuronide; 4,5-Diphenyl-2-oxazolepropionic Acid 1-β-Glucuronide; 1-O-(4,5-Diphenyl-2-oxazolyl)propionyl-β-D-glucopyranosiduronic Acid; Oxaprozin Metabolite; Daypro Metabolite; Oxaprozin-1-O-β-D-Glucuronide; (2-Oxaprolyl)glucuronide
EINECS	Contact for details

Quality Control

Our Oxaprozin-1-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay results, and chromatographic data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥95.0%
Assay (HPLC)	97.0% - 102.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.