Description

Antithrombin Iii is a critical serine protease inhibitor and a key regulator of the blood coagulation cascade. Its primary function is to inactivate thrombin and other coagulation factors, making it essential for maintaining normal hemostasis and preventing pathological thrombosis. This high-purity glycoprotein is indispensable for research and development in the pharmaceutical and diagnostic industries, particularly in the formulation of anticoagulant therapies and clinical assay standards.

Application

• Pharmaceutical Active Ingredient: Core component in the development and production of therapeutic anticoagulants and antithrombin concentrates for treating hereditary or acquired deficiencies.
• Clinical Diagnostic Reagents: Used as a standard or key reagent in assays to measure antithrombin activity or antigen levels in human plasma for thrombophilia testing.
• Biochemical Research: Essential tool for studying the mechanisms of blood coagulation, fibrinolysis, and serine protease inhibition pathways in vitro.
• Reference Standard: Serves as a purity and potency standard for quality control in the manufacturing of related biopharmaceutical products.
• Cell Culture & Protein Studies: Utilized in specialized cell culture media and experiments investigating protein-protein interactions within the coagulation system.

Basic Information

Product Name	Antithrombin Iii
CAS No.	90170-80-2
Molecular Formula	Contact for details
Molecular Weight	~58 kDa
Synonyms	Antithrombin III; ATIII; AT 3; Serpin C1; Heparin Cofactor; Antithrombin; Antithrombin-3; Antithrombin III Human; AT-III
EINECS	Contact for details

Quality Control

Our Antithrombin III is manufactured and tested under strict quality systems. Each batch is characterized to ensure identity, purity, and functional activity, aligning with relevant biological standard requirements. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC/SDS-PAGE), specific activity, endotoxin levels, and sterility is provided with every shipment to guarantee consistency and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or solid
Identification (HPLC/Activity)	Conforms to standard
Purity (SDS-PAGE)	> 95%
Specific Activity	> 5 units/mg protein
Protein Content (Biuret)	Contact for details
Endotoxin	< 1.0 EU/mg
Solubility	Soluble in water or buffered saline

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.