Description

Leukotriene A4 Hydrolase (Human Recombinant) is a purified, catalytically active enzyme critical for the biosynthesis of pro-inflammatory lipid mediators. This high-purity recombinant protein is essential for biochemical research, drug discovery, and the development of assays targeting the leukotriene pathway. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and diagnostic developers focused on inflammation, allergy, and respiratory diseases.

Application

• Enzymatic Activity Studies: Used as a key reagent to study the kinetics and inhibition of the LTA4H enzyme in vitro.
• Drug Discovery & Screening: Serves as a target protein in high-throughput screening (HTS) campaigns to identify novel anti-inflammatory compounds.
• Biochemical Assay Development: Essential for developing and validating ELISA, fluorescence-based, or colorimetric assays to measure LTB4 production or LTA4H activity.
• Inflammation Research: A vital tool for investigating the role of leukotrienes in disease models related to asthma, arthritis, and cardiovascular conditions.
• Protein-Protein Interaction Studies: Used to investigate the binding partners and regulatory mechanisms of LTA4H in cellular signaling pathways.
• Reference Standard: Acts as a purity-qualified standard for the quantification and identification of LTA4H in experimental samples.

Basic Information

Product Name	Leukotriene A4 Hydrolase (Human Recombinant)
CAS No.	90119-07-6
Molecular Formula	Contact for details
Molecular Weight	~69 kDa (monomer)
Synonyms	LTA4 Hydrolase; LTA4H; Leukotriene A-4 Hydrolase; Epoxide Hydrolase 3; EC 3.3.2.6; Leukotriene A4 Hydrolase (Cytosolic); Recombinant Human LTA4H
EINECS	Contact for details

Quality Control

Our recombinant enzyme is produced under stringent conditions and undergoes comprehensive analytical testing to ensure high biological activity and purity. Each batch is characterized by SDS-PAGE, activity assays, and endotoxin testing. Certificates of Analysis (COA) detailing purity, specific activity, and storage buffer composition are provided to guarantee consistency and performance for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at ≤ -20°C in aliquots to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the vial is equilibrated to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow solution
Purity (SDS-PAGE)	≥ 95%
Specific Activity	≥ XX units/mg (Contact for details)
Protein Concentration	XX mg/mL (Contact for details)
Buffer Composition	XX mM Tris, XX mM NaCl, pH X.X, X% Glycerol
Endotoxin Level	< 1.0 EU/µg
Identification (Activity)	Converts LTA4 to LTB4

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.