Description

Erabutoxin B is a potent, short-chain neurotoxic peptide isolated from the venom of the sea snake *Laticauda semifasciata*. This compound is a valuable biochemical tool for the selective and irreversible blockade of postsynaptic nicotinic acetylcholine receptors (nAChRs). Researchers in neurobiology, pharmacology, and toxicology utilize Erabutoxin B CAS NO 9083-23-2 as a critical ligand for studying receptor structure, function, and for the development of novel therapeutic agents targeting neuromuscular disorders.

Application

• Neuroscience Research: As a specific antagonist for muscle-type and neuronal α7 nAChRs to investigate synaptic transmission and signal transduction pathways.
• Pharmacological Studies: Used in competitive binding assays to screen and characterize potential drugs or toxins that interact with nicotinic acetylcholine receptors.
• Structural Biology: Serves as a model protein for X-ray crystallography and NMR studies to understand protein-receptor interactions at the atomic level.
• Toxicology & Venom Research: A reference standard for analyzing sea snake venom composition and for developing antivenoms or diagnostic tools.
• Biochemical Tool Development: Conjugation with fluorescent or affinity tags (e.g., biotin) to create probes for receptor localization and purification.
• Drug Discovery Platforms: Employed in high-throughput screening (HTS) systems to identify novel modulators of cholinergic signaling for conditions like myasthenia gravis, Alzheimer's disease, and chronic pain.

Basic Information

Product Name	Erabutoxin B
CAS No.	9083-23-2
Molecular Formula	C184H281N55O55S7
Molecular Weight	~4230.9 g/mol
Synonyms	Erabutoxin B; Laticotoxin a; Sea Snake Neurotoxin; Ls III; *Laticauda semifasciata* Toxin; Short Neurotoxin; Postsynaptic Neurotoxin; Acetylcholine Receptor Antagonist; EB; ErB
EINECS	Contact for details

Quality Control

Our Erabutoxin B is produced and handled under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and bioactivity. We adhere to rigorous quality testing protocols suitable for research-grade biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, consider aliquoting to avoid repeated freeze-thaw cycles. Allow the vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Biological Activity (nAChR binding assay)	Fully active
Endotoxin Level	< 1.0 EU/µg
Solubility	Soluble in water or aqueous buffers
Protein Content (UV)	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.