Description

Thrombosthenin is a contractile protein complex derived from blood platelets, playing a fundamental role in clot retraction and platelet shape change. Its primary value lies in its use as a critical biochemical reagent for studying platelet physiology, hemostasis, and thrombus formation. This makes it an essential material for researchers and developers in the fields of hematology, cardiovascular disease research, and diagnostic assay development. High-purity Thrombosthenin is vital for ensuring reproducible and accurate experimental results in both academic and industrial R&D settings.

Application

• Biochemical Research: Used as a standard or substrate in studies of platelet contractile mechanisms, cytoskeletal dynamics, and signal transduction pathways.
• Diagnostic Development: Serves as a key component in the development and calibration of in vitro diagnostic (IVD) assays for platelet function disorders.
• Pharmaceutical Screening: Employed in high-throughput screening platforms to identify and evaluate novel anti-thrombotic or hemostatic drug candidates.
• Enzymology Studies: Acts as a source for platelet-derived enzymes and proteins involved in the blood coagulation cascade.
• Cell Biology: Utilized in research focusing on cell adhesion, aggregation, and the role of the platelet cytoskeleton.
• Reference Standard: Provides a purified protein standard for quality control in related bioprocesses and assay validation.

Basic Information

Product Name	Thrombosthenin
CAS No.	9079-92-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Platelet Actomyosin; Thrombosthenin A; Thrombosthenin M; Platelet Contractile Protein; Clot Retraction Protein; Thrombocytic Actomyosin; Platelet Thrombosthenin
EINECS	Contact for details

Quality Control

Our Thrombosthenin is produced and handled under stringent quality management protocols to ensure batch-to-batch consistency and biological activity. Each lot is characterized for purity and functional integrity using appropriate analytical methods. A comprehensive Certificate of Analysis (COA), detailing specifications and test results, is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For short-term use, keep at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or suspension
Identification (Functional)	Positive for ATPase activity and/or clot retraction
Purity (SDS-PAGE)	≥ 90% (Major bands corresponding to actin and myosin)
Protein Content (Biuret/BCA)	≥ 90% of dry weight
Biological Activity	Lot-specific activity provided on COA
Solubility	Soluble in appropriate low-ionic-strength buffers
Endotoxin	< 1.0 EU/mg (where specified)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.