Description

Fibrinase CAS NO 9065-96-7 is a proteolytic enzyme complex, also known as plasmin, derived from bovine plasma or through recombinant technology. This enzyme is critical for its specific ability to degrade fibrin clots, making it an essential biochemical tool in life science research and therapeutic development. It is primarily utilized by pharmaceutical R&D teams, diagnostic manufacturers, and academic researchers focused on hemostasis, thrombosis, and fibrinolysis pathways.

Application

• Biopharmaceutical Research: Used as a key reagent in studies of the fibrinolytic system, thrombosis models, and the development of thrombolytic agents.
• Diagnostic Kit Manufacturing: Serves as a critical component in the production of in-vitro diagnostic (IVD) kits for assessing fibrinogen levels, plasminogen activity, and other coagulation parameters.
• Cell Culture & Tissue Engineering: Employed to dissociate cells from fibrin matrices or to modify extracellular matrix components in 3D cell culture systems.
• Biochemical Standardization: Acts as a reference standard for calibrating assays that measure plasmin activity or for quality control in related enzyme production.
• Therapeutic Agent Development: Investigated for use in targeted therapies, including localized fibrinolysis in conditions like intraocular hemorrhage or as a component of novel drug delivery systems.

Basic Information

Product Name	Fibrinase
CAS No.	9065-96-7
Molecular Formula	N/A (Protein)
Molecular Weight	Approx. 88 kDa (Plasmin)
Synonyms	Plasmin; Fibrinolysin; Actase; Thrombolysin; Serum Tryptase; Plasmin Human; EC 3.4.21.7
EINECS	Contact for details

Quality Control

Our Fibrinase is produced and tested under stringent quality management systems. Each batch is characterized for specific activity, purity, and the absence of contaminating proteases. A comprehensive Certificate of Analysis (COA) is provided, detailing results for key parameters including activity (IU/mg), protein content, and sterility where applicable, ensuring it meets the rigorous demands of research and diagnostic applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized powder at -20°C or below. Reconstituted solutions should be aliquoted and stored at -70°C to prevent autodegradation. The product is hygroscopic (moisture-sensitive); allow vials to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Activity)	Conforms (Chromogenic substrate assay)
Specific Activity	≥ 10 IU/mg protein
Protein Content (Biuret)	≥ 90%
Purity (SDS-PAGE)	Single major band
Solubility	Clear, colorless solution in buffer
Loss on Drying	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.