Description

Merrifield Resin CAS NO 9036-15-1 is a cross-linked polystyrene polymer functionalized with chloromethyl groups, serving as a fundamental solid support for solid-phase peptide synthesis (SPPS). This versatile reagent enables the efficient, stepwise assembly of peptides with high purity and simplified purification. It is an essential tool for researchers and manufacturers in pharmaceutical development, biotechnology, and combinatorial chemistry.

Application

• Solid-Phase Peptide Synthesis (SPPS): The primary application, used as an insoluble polymeric support for the Fmoc or Boc synthesis of peptides, oligonucleotides, and other organic molecules.
• Combinatorial Chemistry: Employed in the generation of diverse chemical libraries for high-throughput screening in drug discovery.
• Organic Synthesis Scaffold: Acts as a reusable solid support for multi-step organic reactions, facilitating easy separation of products from reagents.
• Ligand Immobilization: Used to anchor catalysts, reagents, or scavengers for use in polymer-supported synthesis and purification.
• Bioconjugation & Protein Research: Serves as a matrix for immobilizing proteins or other biomolecules for study or purification purposes.
• Academic & Industrial R&D: A standard reagent in research laboratories for developing novel synthetic methodologies and bioactive compounds.

Basic Information

Product Name	Merrifield Resin
CAS No.	9036-15-1
Molecular Formula	(C9H9Cl)n • (C8H8)m
Molecular Weight	N/A (Polymer)
Synonyms	Chloromethylated Polystyrene; Polystyrene-co-divinylbenzene chloromethylated; Merrifield's Peptide Resin; Chloromethyl Polystyrene Resin; SPPS Resin; 2-Chloroethyl Polystyrene Resin; Cross-linked Chloromethyl Polystyrene; Macroporous Poly(styrene-co-divinylbenzene) chloromethylated
EINECS	Contact for details

Quality Control

Our Merrifield Resin is manufactured under strict quality management systems. Each batch is characterized for critical parameters including chlorine content (loading capacity), particle size, and swelling properties to ensure consistent performance in synthesis. Certificates of Analysis (COA) detailing lot-specific data are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. Under these conditions, the resin is stable for extended periods.

Specification

Item	Specification
Appearance	White to off-white beads
Chlorine Content (Loading)	0.5 - 1.5 mmol/g (Typical)
Mesh Size	100-200 mesh (or as specified)
Crosslinking (Divinylbenzene)	1-2% (or as specified)
Swelling Volume (in DCM)	4.0 - 8.0 mL/g
Moisture Content	< 1.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.