Description

Blood-Coagulation Factor XI is a vital plasma glycoprotein and serine protease zymogen essential for the intrinsic pathway of blood coagulation. Its primary commercial value lies in its critical role in diagnostic reagent manufacturing and advanced life science research, particularly in the study of hemostasis and thrombosis. This high-purity biochemical is indispensable for pharmaceutical developers, clinical diagnostics manufacturers, and research institutions focused on hematology and coagulation disorders.

Application

• Diagnostic Reagent Manufacturing: A key component in clinical assays for measuring activated partial thromboplastin time (aPTT) and diagnosing coagulation factor deficiencies.
• Pharmaceutical Research & Development: Used as a reference standard and active ingredient in the development of hemostatic agents and therapies for bleeding disorders like Hemophilia C.
• Life Science Research: Essential for in vitro studies of the contact activation pathway, thrombosis models, and fundamental biochemical research on protease cascades.
• Quality Control & Standardization: Serves as a calibration standard in QC laboratories for ensuring the accuracy and consistency of coagulation testing systems and reagents.
• Biochemical Production: Used as a starting material or intermediate in the production of more complex coagulation factor concentrates and related biopharmaceuticals.

Basic Information

Product Name	Blood-Coagulation Factor XI
CAS No.	9035-65-8
Molecular Formula	Contact for details
Molecular Weight	Approx. 160,000 Da (dimer)
Synonyms	Factor XI; FXI; Plasma Thromboplastin Antecedent (PTA); Antihemophilic Factor C; Coagulation Factor XI; F11; Hemophilia C Factor; Contact Activation Coagulation Factor
EINECS	Contact for details

Quality Control

Our Blood-Coagulation Factor XI is manufactured and tested under stringent quality systems. Each batch is characterized for identity, purity, and functional activity to ensure it meets the exacting standards required for diagnostic and research applications. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC/SDS-PAGE), specific activity, and absence of contaminating proteases is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C or below. This product is hygroscopic (moisture-sensitive). Avoid repeated freeze-thaw cycles. Aliquot into working volumes upon first thaw to maintain optimal activity.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or frozen solution
Identification (IR / Electrophoresis)	Conforms to standard
Purity (SDS-PAGE)	> 95%
Assay (Functional Activity)	> 80% of labeled activity
Specific Activity	Contact for details
pH (in solution)	6.5 - 7.5
Endotoxin	< 1.0 EU/mg
Moisture Content (for lyophilized form)	< 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.