Description

Cytochrome P 450 CAS NO 9035-51-2 is a superfamily of heme-containing monooxygenase enzymes critical for the metabolism of a vast array of endogenous and exogenous compounds. Its primary commercial value lies in its indispensable role as a catalyst in drug metabolism studies, toxicology screening, and the biosynthesis of steroids and other lipids. This makes it essential for pharmaceutical R&D laboratories, contract research organizations (CROs), and biotechnology companies focused on drug discovery and development, where reliable enzyme activity is paramount for accurate data.

Application

• Drug Metabolism and Interaction Studies (DMPK): Used in vitro to predict hepatic clearance, identify metabolic pathways, and assess drug-drug interaction potential via enzyme inhibition or induction.
• High-Throughput Toxicity Screening: Employed in assays to evaluate the bioactivation of prodrugs or the generation of reactive metabolites that may cause hepatotoxicity.
• Pharmaceutical R&D and Lead Optimization: Critical for characterizing the metabolic stability and pharmacokinetic profiles of new chemical entities (NCEs) during the drug discovery pipeline.
• Enzyme Kinetics and Characterization: Serves as a standard reagent for studying the catalytic mechanisms, substrate specificity, and inhibition kinetics of specific CYP isoforms.
• Biosynthesis Research: Utilized in the study and production of sterols, fatty acids, vitamins, and other bioactive lipids in metabolic engineering.
• Environmental Toxicology: Applied in research to understand the metabolism and detoxification pathways of pesticides, industrial chemicals, and environmental pollutants.

Basic Information

Product Name	Cytochrome P 450
CAS No.	9035-51-2
Molecular Formula	N/A (Protein complex)
Molecular Weight	Varies by isoform (~45-60 kDa)
Synonyms	Cytochrome P450; CYP450; CYP; Heme-thiolate monooxygenase; P450 enzyme; Microsomal monooxygenase; Xenobiotic monooxygenase; Mixed-function oxidase; Aryl hydrocarbon hydroxylase
EINECS	Contact for details

Quality Control

Our Cytochrome P 450 is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and optimal enzymatic activity. Each lot is characterized for specific isoform content, purity, and functional activity using advanced analytical techniques. Certificates of Analysis (COA) detailing specifications such as protein concentration, specific content (pmol/mg protein), and catalytic activity are provided to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -70°C or below in aliquots to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use. Handle under appropriate laboratory conditions.

Specification

Item	Specification
Source	Recombinant or Human Liver Microsomes
Isoform(s)	CYP1A2, 2C9, 2C19, 2D6, 3A4, etc.
Protein Concentration	≥ 5 mg/mL
Specific Content	≥ 300 pmol/mg protein
Purity (SDS-PAGE)	≥ 90%
Activity (Substrate-specific)	Contact for details
Identification (IR / Spectra)	Conforms to standard
Appearance	Reddish-brown suspension or lyophilized powder

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.