Description

Hemoglobin Zurich is a naturally occurring, stable variant of human hemoglobin characterized by a specific amino acid substitution that alters its oxygen-binding properties. This unique biochemical profile makes it a valuable reference standard and research tool for studying hemoglobinopathies, oxygen transport kinetics, and blood substitute development. It is essential for researchers and developers in the fields of clinical diagnostics, hematology research, and biopharmaceutical development who require high-purity, well-characterized hemoglobin derivatives.

Application

• Biochemical Research: Used as a critical reference standard in studies of hemoglobin structure, function, and stability, particularly for investigating oxygen affinity and allosteric regulation.
• Clinical Diagnostics Development: Serves as a control material in the development and calibration of diagnostic assays for detecting hemoglobin variants and related blood disorders.
• Hematology Studies: Employed in laboratory investigations into sickle cell disease, thalassemias, and other hemoglobinopathies to understand disease mechanisms.
• Blood Substitute & Oxygen Carrier Research: Acts as a model compound in preclinical research aimed at developing hemoglobin-based oxygen carriers (HBOCs) and artificial blood products.
• Educational & Reference Material: Supplied to academic and institutional laboratories for teaching and advanced research in protein chemistry and physiology.
• Quality Control in Bioprocessing: Utilized as a process control standard in the purification and analysis of hemoglobin-related biopharmaceuticals.

Basic Information

Product Name	Hemoglobin Zurich
CAS No.	9035-33-0
Molecular Formula	C2952H4664N812O832S8Fe4 (Approximate for human hemoglobin tetramer)
Molecular Weight	~64,500 Da (for tetramer)
Synonyms	Hb Zurich; Hemoglobin β63 (E7) His→Arg; Hemoglobin variant Zurich; Oxyhemoglobin Zurich; Methemoglobin Zurich; Deoxyhemoglobin Zurich; Human Hemoglobin Zurich; Hb ZRH
EINECS	Contact for details

Quality Control

Our Hemoglobin Zurich is produced and handled under controlled conditions to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is characterized using advanced analytical techniques including electrophoresis and spectrophotometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional assays is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the product to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	Dark red to brown lyophilized powder or solution
Identification (Electrophoresis)	Conforms to standard for Hemoglobin Zurich
Purity (HPLC/Electrophoresis)	≥ 90% (Hemoglobin Zurich)
Assay (Spectrophotometric)	Reported on COA
Methemoglobin Content	< 10%
Solubility	Clear solution in buffer
Protein Concentration	Reported on COA
Endotoxin	< 1.0 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.