Description

Hemoglobin N Baltimore is a naturally occurring variant of human hemoglobin, characterized by a specific amino acid substitution in the β-globin chain. This protein is of significant interest in biochemical research and diagnostic development due to its altered oxygen-binding properties compared to normal adult hemoglobin (HbA). It serves as a critical reference material and reagent for researchers and manufacturers in the life sciences, clinical diagnostics, and pharmaceutical sectors, enabling studies in hematology, hemoglobinopathy screening, and the calibration of analytical instruments.

Application

• Biochemical Research: Used as a standard or model protein in studies of hemoglobin structure, function, and ligand-binding kinetics.
• Diagnostic Reagent Manufacturing: Serves as a key component in the production of control materials and calibrators for clinical analyzers used in hemoglobin variant testing.
• Hematology Reference Standards: Provides a defined benchmark for quality control in laboratories performing electrophoresis, chromatography, or mass spectrometry for hemoglobinopathies.
• Pharmaceutical Development: Utilized in research exploring oxygen therapeutics and blood substitute technologies.
• Educational Purposes: Employed in academic settings for teaching advanced concepts in protein chemistry and molecular biology.

Basic Information

Product Name	Hemoglobin N Baltimore
CAS No.	9035-12-5
Molecular Formula	Contact for details
Molecular Weight	~64,500 Da (for tetramer)
Synonyms	Hb N Baltimore; Hemoglobin variant N Baltimore; β-95 (FG2) Lys→Glu Hemoglobin; Hemoglobin Norfolk (historical); HBB: c.287A>G; Unii-Contact for details
EINECS	Contact for details

Quality Control

Our Hemoglobin N Baltimore is produced and handled under stringent quality management protocols. Each batch undergoes rigorous analytical testing to ensure identity, purity, and functional consistency. Certificates of Analysis (COA) are provided, detailing key parameters such as spectral purity, methemoglobin content, and electrophoretic mobility. We adhere to relevant guidelines for biological reference materials to support your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C or below. Avoid repeated freeze-thaw cycles. This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Identification (Electrophoresis)	Consistent with Hemoglobin N Baltimore
Purity (HPLC)	≥ 95% (of total hemoglobin)
Methemoglobin Content	< 5%
Protein Concentration	As per COA
Solvent/Buffer	Typically in phosphate buffer or water
Biological Activity (O2 binding)	Altered relative to HbA, as expected for variant

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.