Description

Hemoglobin Manitoba is a naturally occurring variant of human hemoglobin, identified by the CAS registry number 9035-09-0. This protein is of significant interest in biochemical research and diagnostic applications due to its altered oxygen-binding properties compared to standard hemoglobin A. It serves as a critical reference material and reagent for laboratories focused on hematology, clinical diagnostics, and genetic research. Industries requiring high-purity biological standards for quality control and method development will find this product essential.

Application

• Clinical Diagnostic Reference Standard: Used as a calibrator or control material in assays for hemoglobin variants and thalassemia screening.
• Biochemical Research: Essential for studying protein structure-function relationships, oxygen affinity, and allosteric regulation in hemoglobins.
• Hematology Studies: Employed in research investigating the pathophysiology and stability of rare hemoglobinopathies.
• Pharmaceutical Development: Acts as a model compound in the development of oxygen therapeutics and blood substitute technologies.
• Educational Purposes: Serves as a high-quality teaching tool in university-level biochemistry and medical laboratory science courses.
• Method Validation: Used to validate and calibrate analytical techniques such as HPLC, capillary electrophoresis, and mass spectrometry in clinical labs.

Basic Information

Product Name	Hemoglobin Manitoba
CAS No.	9035-09-0
Molecular Formula	Contact for details
Molecular Weight	~64,500 Da (for tetramer)
Synonyms	Hb Manitoba; Hemoglobin α2β2 102(G4)Asn→Ser; Hemoglobin Variant Manitoba; Hemoglobin (Human Manitoba Variant); Oxyhemoglobin Manitoba; Deoxyhemoglobin Manitoba; Methemoglobin Manitoba
EINECS	Contact for details

Quality Control

Our Hemoglobin Manitoba is produced and handled under stringent quality management protocols. Each batch is subjected to rigorous identity confirmation and purity analysis using advanced techniques including electrophoresis, HPLC, and spectrophotometry. We provide comprehensive Certificates of Analysis (COA) detailing purity, concentration, and physical characteristics to ensure it meets the exacting standards required for research and diagnostic applications. The material is suitable for use as a reference standard in regulated laboratory environments.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture. Avoid repeated freeze-thaw cycles. For in-use aliquots stored at 2-8°C, use within a specified period.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Identification (Electrophoresis/HPLC)	Conforms to Hemoglobin Manitoba profile
Purity (HPLC)	≥ 95% (by area)
Assay (Spectrophotometric)	Contact for details
Solubility	Clear solution in buffer
Endotoxin	< 1.0 EU/mg (if applicable)
Biological Activity (O2 affinity)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.