Description

Hemoglobin Chesapeake is a naturally occurring variant of human hemoglobin, characterized by a specific amino acid substitution in the β-globin chain. This protein is of significant interest in biochemical and clinical research for studying the structure-function relationships of hemoglobin and its role in oxygen transport disorders. It serves as a critical reference material for laboratories investigating hemoglobinopathies, oxygen affinity, and protein stability. Key users include pharmaceutical R&D teams, diagnostic kit manufacturers, and academic institutions focused on hematology and molecular biology.

Application

• Biochemical Research Standard: Used as a purified reference protein in studies of hemoglobin structure, oxygen-binding kinetics, and allosteric regulation.
• Clinical Diagnostics Development: Serves as a control or calibrator in the development of diagnostic assays for detecting hemoglobin variants and related blood disorders.
• Pharmaceutical R&D: Employed in research programs targeting blood substitutes, oxygen therapeutics, and treatments for sickle cell disease.
• Hematology Studies: Essential for in-vitro studies modeling the effects of specific mutations on red blood cell function and stability.
• Educational & Reference Material: Supplied to academic and teaching laboratories for advanced coursework in biochemistry, physiology, and medical technology.
• Biotechnology Reagent: Used in the development and validation of analytical techniques such as HPLC, electrophoresis, and mass spectrometry for protein analysis.

Basic Information

Product Name	Hemoglobin Chesapeake
CAS No.	9034-58-6
Molecular Formula	Contact for details
Molecular Weight	~64,500 Da (for tetramer)
Synonyms	Hb Chesapeake; Hemoglobin variant Chesapeake; α-2 β-2(92)Arg->Leu; HBB: c.277C>T; Hemoglobin α2β2 92(F8) Arg→Leu; Unstable Hemoglobin Chesapeake; High Oxygen Affinity Hemoglobin; Oxyhemoglobin Chesapeake
EINECS	Contact for details

Quality Control

Our Hemoglobin Chesapeake is produced and handled under strict quality protocols to ensure batch-to-batch consistency and purity suitable for research applications. Each lot is characterized using advanced analytical techniques, including electrophoresis and spectrophotometry, to confirm identity and functional integrity. A comprehensive Certificate of Analysis (COA) detailing purity, concentration, and physical state is provided with every shipment. We adhere to relevant guidelines for biological materials to ensure product reliability for your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C or below. Avoid repeated freeze-thaw cycles. This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture. Store in a cool, dry, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Identification (Electrophoresis)	Conforms to standard for Hb Chesapeake
Purity (HPLC)	≥ 90% (by area)
Protein Concentration	As per COA
Methemoglobin Content	< 5%
Solubility	Clear solution in buffer
Biological Activity (O2 affinity)	Contact for details
Endotoxin	< 1.0 EU/mg (if specified)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.