Description

Hemoglobin Bristol is a specific variant of the oxygen-carrying protein found in red blood cells, identified by the CAS number 9034-56-4. This compound is of significant interest in biochemical research and diagnostic development due to its unique structural and functional properties. It serves as a critical reference material and reagent for scientists and manufacturers in the fields of clinical diagnostics, hematology research, and biotechnology.

Application

• Clinical Reference Standard: Used as a calibrator and control material in diagnostic assays for hemoglobinopathies and blood disorders.
• Biochemical Research: Serves as a model protein for studying oxygen binding kinetics, protein stability, and mutation effects.
• Diagnostic Kit Manufacturing: A key component in the production of test kits for abnormal hemoglobin detection.
• Hematology Studies: Employed in laboratory investigations of red blood cell function and disease mechanisms.
• Pharmaceutical Development: Potential use in research for blood substitute and oxygen therapeutic agents.
• Educational & Quality Control: Utilized in academic settings and by quality control laboratories for method validation and training.

Basic Information

Product Name	Hemoglobin Bristol
CAS No.	9034-56-4
Molecular Formula	C2952H4664N812O832S8Fe4
Molecular Weight	~64,500 Da (for α2β2 tetramer)
Synonyms	Hb Bristol; Hemoglobin variant Bristol; Unstable hemoglobin Bristol; Hemoglobin (human variant Bristol); Oxyhemoglobin Bristol; Deoxyhemoglobin Bristol; Methemoglobin Bristol; HBB 67 (E11) Val→Asp
EINECS	Contact for details

Quality Control

Our Hemoglobin Bristol is produced and handled under stringent quality protocols. Each batch is characterized to ensure identity, purity, and functional integrity, meeting the exacting standards required for research and diagnostic applications. Certificates of Analysis (COA) detailing specifications such as purity (by HPLC), spectral properties, and functional activity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	Lyophilized powder
Identification (IR / HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Protein Content (Biuret)	≥ 90%
Methemoglobin Content	< 5%
Oxygen Binding Capacity	Assessed per batch
Solubility	Soluble in buffer (e.g., phosphate buffer, pH 7.0-7.4)
Endotoxin	< 1.0 EU/mg (where specified)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.