Description

Phosphoribosylformylglycinamidine Synthase is a critical enzyme involved in the de novo purine biosynthesis pathway, specifically catalyzing the conversion of formylglycinamidine ribonucleotide (FGAM) to formylglycinamidine ribonucleotide (FGAR). This compound is essential for research and development in biochemistry and molecular biology, particularly in studies focused on nucleotide metabolism and enzyme kinetics. It is primarily utilized by pharmaceutical researchers, academic institutions, and diagnostic manufacturers engaged in metabolic pathway analysis and drug discovery targeting purine metabolism.

Application

• Biochemical Research: Used as a key reagent in enzymatic assays to study the purine biosynthesis pathway and its regulation.
• Pharmaceutical Development: Serves as a target or tool compound in screening for potential inhibitors for anticancer or antimicrobial drug discovery.
• Diagnostic Manufacturing: Employed in the formulation of specialized diagnostic kits for inborn errors of metabolism related to purine synthesis.
• Academic Studies: Essential for university and research institute laboratories focusing on enzymology, metabolic engineering, and cellular biochemistry.
• Enzyme Production & Purification: Used as a standard or reference material in processes for the production and quality control of related enzymatic products.

Basic Information

Product Name	Phosphoribosylformylglycinamidine Synthase
CAS No.	9032-84-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	FGAM Synthetase; AIR Synthetase; 5'-Phosphoribosylformylglycinamidine Synthase; FGAMS; Pur5; EC 6.3.5.3; Formylglycinamidine ribonucleotide synthase; Phosphoribosylformylglycinamidine cyclo-ligase
EINECS	Contact for details

Quality Control

Our Phosphoribosylformylglycinamidine Synthase is produced under stringent conditions to ensure high purity and consistent enzymatic activity. Each batch undergoes rigorous quality testing, including assessment of specific activity and purity via electrophoresis and chromatography. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your research and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture. For short-term use, aliquoting is recommended to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Activity)	Conforms
Specific Activity	≥ [Value] units/mg protein
Purity (SDS-PAGE)	≥ 90%
Protein Content (Bradford)	≥ [Value] mg/vial
Endotoxin Level	< 1.0 EU/μg
Storage Buffer	Specified phosphate or Tris buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.