Description

Sphingomyelinase is a crucial hydrolytic enzyme that catalyzes the cleavage of sphingomyelin to produce phosphocholine and ceramide. This reaction is fundamental to sphingolipid metabolism and cell signaling pathways, making the enzyme an essential biochemical tool. It is primarily utilized by researchers in life sciences and professionals in the pharmaceutical industry for studying lipid metabolism, apoptosis, and membrane biology.

Application

• Biochemical Research: A key reagent for in vitro studies of sphingolipid metabolism, cell signaling cascades, and lipid raft dynamics.
• Pharmaceutical Development: Used in drug discovery and development targeting metabolic disorders, neurodegenerative diseases, and cancer research related to ceramide pathways.
• Diagnostic Assays: Employed in enzymatic assays and diagnostic kits to measure sphingomyelin levels or related enzymatic activities in clinical samples.
• Cell Biology Studies: Essential for investigating membrane structure, cell cycle regulation, and programmed cell death (apoptosis).
• Enzyme Characterization: Serves as a standard or substrate for characterizing other enzymes or inhibitors within the phospholipase family.

Basic Information

Product Name	Sphingomyelinase
CAS No.	9031-54-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Sphingomyelin phosphodiesterase; Sphingomyelin phosphodiesterase D; SMase; Acid sphingomyelinase (when referring to specific isoform); Alkaline sphingomyelinase (when referring to specific isoform); Sphingomyelin cholinephosphohydrolase; EC 3.1.4.12
EINECS	Contact for details

Quality Control

Our Sphingomyelinase is produced and tested under strict quality management protocols to ensure high purity, specific activity, and batch-to-batch consistency suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as activity units, protein content, and purity. We adhere to relevant quality guidelines to support our global clientele in pharmaceutical and academic research.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and enzymatic activity.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Identification (IR)	Conforms
Specific Activity	≥ [Value] units/mg protein
Protein Content (Biuret)	≥ [Value] %
Purity (SDS-PAGE)	≥ [Value] %
pH (for solutions)	[Value] - [Value]
Endotoxin (LAL)	< [Value] EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.