Description

Ceruloplasmin, Human is a vital blue copper-containing glycoprotein that serves as the primary copper-carrying enzyme in human plasma. Its core function is in the regulation of iron metabolism through its ferroxidase activity, making it essential for maintaining proper iron homeostasis. This high-purity protein is critical for research in biochemistry, hematology, and for use as a diagnostic reagent and reference standard in clinical and pharmaceutical development.

Application

• Biochemical Research & Diagnostic Development: Used as a key reagent in studies of Wilson's disease, Menkes disease, and other disorders of copper and iron metabolism.
• Clinical Diagnostics: Serves as a critical component and calibrator in immunoassay kits for the quantitative measurement of ceruloplasmin levels in human serum.
• Pharmaceutical Reference Standard: Employed as a purity standard in the development and quality control of therapeutic proteins and related biopharmaceuticals.
• Enzymology Studies: Utilized to investigate ferroxidase and amine oxidase activity, antioxidant properties, and its role in inflammatory processes.
• Cell Culture & In Vitro Models: Applied in specialized cell culture media and research models to study the effects of ceruloplasmin on cellular iron export and oxidative stress.

Basic Information

Product Name	Ceruloplasmin, Human
CAS No.	9031-37-2
Molecular Formula	Contact for details
Molecular Weight	~132 kDa (Glycoprotein)
Synonyms	Ferroxidase; Caeruloplasmin; CP; Ceruloplasmin (Human); Iron(II):oxygen oxidoreductase; Uteroferrin; Coeruloplasmin; Human Ceruloplasmin
EINECS	Contact for details

Quality Control

Our Ceruloplasmin, Human is produced and tested under stringent conditions to ensure high purity and consistent biological activity. Each lot is characterized for identity, purity, and functional ferroxidase activity. A comprehensive Certificate of Analysis (COA) is provided, detailing results from SDS-PAGE, HPLC, and activity assays. We adhere to relevant quality guidelines suitable for research and diagnostic manufacturing applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider aliquoting and storing at ≤ -20°C. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	Blue-green, lyophilized powder
Identification (SDS-PAGE)	Single band, ~132 kDa
Purity (HPLC)	≥ 95%
Protein Content (Biuret)	≥ 90%
Ferroxidase Activity	≥ 50 U/mg protein
Copper Content (AAS)	6 - 7 atoms per molecule
Solubility	Soluble in water or buffer
Endotoxin (LAL)	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.