Description

Kynurenine 3-Monooxygenase CAS NO 9029-61-2 is a critical enzyme in the kynurenine pathway, a major route for tryptophan catabolism. Its primary function is to catalyze the hydroxylation of L-kynurenine to 3-hydroxykynurenine, a key step influencing neuroactive metabolite production. This makes it an essential research tool for scientists investigating neurological disorders, immune regulation, and cancer metabolism. Researchers in pharmaceutical development, biochemistry, and neuroscience rely on high-activity, pure enzyme preparations to ensure accurate and reproducible experimental results.

Application

• Biochemical Research: Fundamental studies on the kynurenine pathway and its role in cellular metabolism.
• Drug Discovery & Target Validation: Screening and characterization of novel inhibitors for neurological and inflammatory diseases.
• Neuroscience Studies: Investigation of neurotoxicity and neuroprotection mechanisms linked to quinolinic acid and kynurenic acid balance.
• Immunology Research: Exploring the enzyme's role in immune tolerance, T-cell regulation, and inflammatory responses.
• Oncology Research: Studying tumor immunology and the role of tryptophan metabolism in cancer cell immune evasion.
• Enzyme Kinetics & Characterization: Used as a standard in enzymatic assays to determine kinetic parameters and inhibitor constants (Ki).
• Diagnostic Development: Potential component in assay kits for measuring pathway activity in clinical research samples.

Basic Information

Product Name	Kynurenine 3-Monooxygenase
CAS No.	9029-61-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	KMO; Kynurenine 3-Hydroxylase; L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating); EC 1.14.13.9; Kynurenine 3-Mono-oxygenase; Kynurenine 3-Hydroxylase (KMO); Kynurenine 3-Monooxygenase (KMO)
EINECS	Contact for details

Quality Control

Our Kynurenine 3-Monooxygenase is produced and tested under stringent conditions to ensure high specific activity and purity for critical research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as specific activity, protein concentration, and purity. We adhere to rigorous quality standards to guarantee batch-to-batch consistency and reliable performance in your enzymatic assays.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature before opening to minimize moisture condensation. For optimal preservation of enzymatic activity, avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Specific Activity	≥ [Value] units/mg protein
Protein Concentration	Determined by COA
Purity (SDS-PAGE)	≥ 90%
Buffer Composition	Specified per lot
Stability	Stable as recommended for 12 months at -20°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.