Description

3-Hydroxyanthranilate 3,4-Dioxygenase is a crucial enzyme in the kynurenine pathway, responsible for catalyzing the oxidative ring cleavage of 3-hydroxyanthranilate. This enzymatic activity is fundamental for research into tryptophan metabolism, cellular energy regulation, and neuroinflammatory processes. It is an essential biochemical tool for researchers and developers in the fields of pharmaceutical development, metabolic disease research, and neuroscience.

Application

• Biochemical Research: A key reagent for in vitro studies of the kynurenine pathway and tryptophan metabolism.
• Pharmaceutical Development: Used in target validation and screening assays for drugs aimed at modulating neuroinflammation or neurodegenerative diseases.
• Enzyme Kinetics Studies: Employed to study catalytic mechanisms, inhibition, and structure-activity relationships of dioxygenase enzymes.
• Diagnostic Kit Development: Serves as a component in enzymatic assays for measuring metabolite levels in biological samples.
• Academic Research: Utilized in university and institutional labs for fundamental research into metabolic disorders and immune response pathways.

Basic Information

Product Name	3-Hydroxyanthranilate 3,4-Dioxygenase
CAS No.	9029-50-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	3-Hydroxyanthranilic Acid Dioxygenase; 3-Hydroxyanthranilate Dioxygenase; 3HAO; HAAO; 3-Hydroxy-2-aminobenzoate 3,4-dioxygenase; EC 1.13.11.6; 3-Hydroxyanthranilic 3,4-Dioxygenase
EINECS	Contact for details

Quality Control

Our enzyme products are manufactured and tested under stringent quality protocols to ensure batch-to-batch consistency, high specific activity, and purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as activity, protein content, and purity. We support research and industrial applications requiring reliable and reproducible enzymatic performance.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. This product is hygroscopic (moisture-sensitive). Avoid repeated freeze-thaw cycles to maintain optimal enzymatic activity.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Specific Activity	Contact for details
Purity (SDS-PAGE)	≥ 90%
Protein Content	Contact for details
Stabilizers / Buffers	Specified on COA
Activity Assay	Spectrophotometric

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.