Description

Acetaldehyde Dehydrogenase (ALDH) is a critical enzyme that catalyzes the irreversible oxidation of acetaldehyde to acetic acid, playing a vital role in cellular metabolism and detoxification pathways. Its primary commercial value lies in providing a reliable, high-purity biocatalyst for research, diagnostic, and industrial bioprocess applications. This enzyme is essential for biotechnology firms, pharmaceutical R&D departments, and diagnostic kit manufacturers focused on metabolic studies, alcohol metabolism research, and biosensor development.

Application

• Biochemical Research & Assay Development: Used as a key reagent in enzymatic assays to study alcohol metabolism, mitochondrial function, and aldehyde toxicity.
• Diagnostic Kit Manufacturing: Incorporated into clinical diagnostic kits for the quantitative measurement of acetaldehyde or ethanol levels in biological samples.
• Pharmaceutical R&D: Employed in drug discovery programs targeting diseases related to aldehyde accumulation, such as certain cancers and Fanconi anemia.
• Industrial Biocatalysis: Utilized in synthetic pathways for the production of fine chemicals and pharmaceuticals where specific chiral or regio-selective oxidation is required.
• Toxicology & Environmental Testing: Applied in testing protocols to assess metabolic conversion rates and detoxification capacities in various models.
• Food & Beverage Analysis: Used in enzymatic methods for quality control, monitoring fermentation processes, and ensuring product safety.

Basic Information

Product Name	Acetaldehyde Dehydrogenase
CAS No.	9028-91-5
Molecular Formula	N/A (Enzyme)
Molecular Weight	Varies by isoform and source (typically ~54 kDa per subunit)
Synonyms	Aldehyde Dehydrogenase (NAD+); ALDH; Acetaldehyde:NAD+ Oxidoreductase; EC 1.2.1.10; Aldehyde Dehydrogenase (NAD(P)+); Mitochondrial Aldehyde Dehydrogenase; Cytosolic Aldehyde Dehydrogenase
EINECS	Contact for details

Quality Control

Our Acetaldehyde Dehydrogenase is produced and tested under stringent quality management systems. Each lot is characterized for specific activity, purity (via SDS-PAGE), and protein concentration to ensure batch-to-batch consistency and performance reliability. Certificates of Analysis (COA) detailing these parameters are provided with every shipment. We can supply grades suitable for research use (RUO) and can discuss specifications for in-vitro diagnostic (IVD) or higher-grade applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Avoid repeated freeze-thaw cycles. The product is typically supplied as a lyophilized powder or in a buffered glycerol solution; follow the specific storage instructions provided on the accompanying COA and label.

Specification

Item	Specification
Appearance	Lyophilized powder or clear solution
Specific Activity	≥ 5-20 units/mg protein (Contact for specific grade)
Purity (SDS-PAGE)	≥ 90%
Protein Content	Determined by Biuret or Bradford assay
Stabilizers	May contain buffer salts (e.g., phosphate) and glycerol
Activity Assay	Spectrophotometric (NADH formation at 340 nm)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.