Description

Aldehyde Dehydrogenase is a critical oxidoreductase enzyme that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acids, utilizing NAD(P)+ as a cofactor. This enzymatic activity is essential for cellular detoxification and metabolic pathways, making it a vital reagent for biochemical research and industrial biocatalysis. It is extensively utilized by researchers in pharmaceutical development, toxicology studies, and by manufacturers in the production of fine chemicals and diagnostic kits.

Application

• Biochemical Research & Assay Development: A fundamental tool for studying aldehyde metabolism, oxidative stress, and enzyme kinetics in academic and pharmaceutical R&D laboratories.
• Pharmaceutical Testing & Drug Metabolism: Used in in vitro models to investigate the metabolism and detoxification of aldehydes generated from drug compounds, supporting ADME (Absorption, Distribution, Metabolism, and Excretion) studies.
• Diagnostic Kit Manufacturing: A key component in clinical diagnostic assays for measuring biomarkers like blood alcohol (acetaldehyde) or specific metabolic disorders linked to aldehyde accumulation.
• Industrial Biocatalysis: Employed in the synthesis of chiral carboxylic acids and other fine chemicals, offering a green and selective alternative to traditional chemical synthesis.
• Toxicology & Environmental Science: Applied in assays to assess the cytotoxicity and genotoxicity of aldehyde pollutants, aiding in environmental risk assessment.
• Food & Flavor Chemistry: Used in research related to flavor development and the analysis of aldehyde compounds in food products and beverages.

Basic Information

Product Name	Aldehyde Dehydrogenase
CAS No.	9028-88-0
Molecular Formula	N/A (Enzyme)
Molecular Weight	Varies by source and isoform (typically ~50-55 kDa per subunit)
Synonyms	ALDH; Aldehyde:NAD+ oxidoreductase; Aldehyde Oxidoreductase; Acetaldehyde Dehydrogenase; NAD+-dependent Aldehyde Dehydrogenase; EC 1.2.1.3; EC 1.2.1.5
EINECS	Contact for details

Quality Control

Our Aldehyde Dehydrogenase is produced and tested under stringent quality management protocols. Each lot is characterized for specific activity, purity, and stability to ensure consistent performance for critical research and industrial applications. A comprehensive Certificate of Analysis (COA) detailing assay results, protein content, and specific activity is provided with every shipment. We adhere to relevant guidelines for biochemical reagents to support our customers' quality and compliance requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot into smaller volumes after reconstitution to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Specific Activity	≥ [Value] units/mg protein
Protein Content (Biuret)	Contact for details
Purity (SDS-PAGE)	≥ 90%
Stabilizers	May contain glycerol or buffer salts
pH (in solution)	7.0 - 8.0
Residual Moisture (Lyophilized)	< 5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.