Description

Aminoacyl-tRNA Synthetase is a critical class of enzymes essential for the accurate translation of genetic information into functional proteins. These enzymes catalyze the specific attachment of amino acids to their corresponding tRNA molecules, a fundamental step in protein biosynthesis. This product is vital for research and development in biotechnology, pharmaceutical discovery, and molecular biology, where precise control over protein synthesis is required.

Application

• Biochemical Research & Enzymology Studies: Used as a key reagent to study the mechanism and kinetics of aminoacylation, enzyme specificity, and protein-RNA interactions.
• In Vitro Transcription/Translation Systems: An essential component of cell-free protein synthesis platforms for producing proteins, peptides, and non-standard amino acid-containing polypeptides.
• Drug Discovery & Target Validation: Employed in high-throughput screening assays to identify novel inhibitors of aminoacyl-tRNA synthetases, which are promising targets for new antibacterial, antifungal, and antiparasitic agents.
• Diagnostic Kit Development: Utilized in the formulation of kits for studying genetic code translation, tRNA charging, and related metabolic pathways.
• Synthetic Biology & Genetic Engineering: Facilitates the incorporation of unnatural amino acids into proteins, enabling the creation of proteins with novel properties for industrial and therapeutic applications.
• Academic & Educational Use: Serves as a standard enzyme for teaching advanced concepts in biochemistry, molecular genetics, and enzymology laboratories.

Basic Information

Product Name	Aminoacyl-tRNA Synthetase
CAS No.	9028-02-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Aminoacyl Transfer RNA Synthetase; Aminoacyl-tRNA Ligase; ARS; aaRS; tRNA-Aminoacylating Enzyme; Amino Acid-tRNA Ligase; EC 6.1.1.-; Activating Enzyme
EINECS	Contact for details

Quality Control

Our Aminoacyl-tRNA Synthetase is produced and tested under stringent quality management protocols to ensure high purity, specific activity, and batch-to-batch consistency. Each lot is characterized for enzymatic activity and purity profile. Certificates of Analysis (COA) detailing specific activity, purity (via SDS-PAGE), and absence of contaminating nucleases/proteases are provided with every shipment to support your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below in aliquots to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use. Handle under appropriate laboratory conditions.

Specification

Item	Specification
Appearance	Lyophilized powder or solution in buffer
Identification (Activity)	Catalyzes aminoacylation of specific tRNA
Specific Activity	> [Value] units/mg protein
Purity (SDS-PAGE)	> 90%
Protein Concentration	As per COA
Buffer Composition	Specified on COA
Contaminants (DNase/RNase)	Not detected
Endotoxin Level	< 1.0 EU/µg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.