Description

Cathepsin D is a lysosomal aspartic endopeptidase that plays a critical role in intracellular protein catabolism and tissue remodeling. Its precise enzymatic activity makes it an essential reagent for biochemical research and diagnostic development. This product is vital for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors, particularly for studying proteolytic pathways, cancer metastasis, and neurodegenerative diseases.

Application

• Biomedical Research: Used as a key enzyme in studies of apoptosis, autophagy, and protein turnover mechanisms.
• Drug Discovery & Development: Employed as a target or screening tool for inhibitors in oncology and neurology research programs.
• Diagnostic Kit Manufacturing: Serves as a critical component in the development of ELISA and other assay kits for disease biomarker detection.
• Proteomics & Protein Analysis: Utilized for controlled protein digestion and peptide mapping in mass spectrometry workflows.
• Cell Culture & Tissue Engineering: Applied in studies of extracellular matrix degradation and cellular invasion models.
• Biochemical Reagent: Acts as a standard or reference enzyme in enzymatic activity assays and biochemical characterizations.

Basic Information

Product Name	Cathepsin D
CAS No.	9025-26-7
Molecular Formula	Contact for details
Molecular Weight	~42 kDa (Monomer)
Synonyms	Cathepsin D; Cathepsin D Acid Proteinase; Cathepsin D Aspartic Protease; Lysosomal Aspartic Protease; CTSD; EC 3.4.23.5; Aspartyl Cathepsin
EINECS	Contact for details

Quality Control

Our Cathepsin D is produced and tested under stringent quality management systems to ensure batch-to-batch consistency and high biological activity. Each lot is characterized for specific activity, purity, and absence of contaminating proteases. A comprehensive Certificate of Analysis (COA) detailing assay results, purity profile, and stability data is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature before opening to prevent condensation. Aliquot reconstituted material to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	Lyophilized powder
Identification (Activity)	Conforms
Specific Activity	≥ 1,500 units/mg protein
Purity (SDS-PAGE)	≥ 90%
Protein Content (Biuret)	Contact for details
Solubility	Fully soluble in water or buffer
pH Optimum	~3.5 - 5.0
Inhibitor Sensitivity	Inhibited by Pepstatin A

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.