Description

Creatininase Amidohydrolase is a highly specific hydrolytic enzyme that catalyzes the conversion of creatinine to creatine. This precise biocatalytic activity is critical for accurate diagnostic measurements in clinical and research settings. It is an essential reagent for manufacturers of in-vitro diagnostic (IVD) kits, clinical chemistry analyzers, and biochemical research laboratories focused on renal function and muscle metabolism studies.

Application

• Clinical Diagnostics: Core enzymatic component in creatinine assay kits for automated clinical chemistry analyzers to assess kidney function.
• IVD Kit Manufacturing: Used in the formulation of standardized, high-precision test kits for hospitals and diagnostic laboratories.
• Biochemical Research: Employed in enzymatic studies, metabolic pathway analysis, and as a tool enzyme in life science research.
• Point-of-Care Testing (POCT): Integrated into rapid test strips and portable devices for decentralized creatinine testing.
• Veterinary Diagnostics: Adapted for use in veterinary clinical chemistry to monitor renal health in animals.
• Quality Control Reagents: Serves as a reference standard in the production of control sera and calibration solutions.

Basic Information

Product Name	Creatininase Amidohydrolase
CAS No.	9025-13-2
Molecular Formula	N/A (Enzyme)
Molecular Weight	Approx. 45-50 kDa (Source dependent)
Synonyms	Creatininase; Creatinine Amidohydrolase; Creatinine Deiminase; EC 3.5.4.21; Creatinine Hydrolase; Microbial Creatininase
EINECS	Contact for details

Quality Control

Our Creatininase Amidohydrolase is produced and tested under a rigorous quality management system. Each lot is characterized for specific activity, purity, and stability to ensure consistent performance in diagnostic applications. Certificates of Analysis (COA) detailing activity (U/mg), protein content, and purity are provided with every shipment. Production can adhere to relevant guidelines for IVD reagent manufacturing.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or solution
Specific Activity	≥ 10 U/mg protein (Contact for higher grades)
Protein Content (Biuret)	≥ 90%
Identification (Activity)	Conforms
pH (in solution)	6.5 - 7.5
Contaminant Activity (Urease)	≤ 0.01%
Solubility	Clear, colorless solution in buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.