Description

L-Ornithine Decarboxylase From Escherichia Coli is a highly specific enzyme that catalyzes the decarboxylation of L-ornithine to putrescine, a key step in polyamine biosynthesis. This reaction is fundamental for cellular growth and proliferation, making the enzyme a critical research and diagnostic tool. It is essential for biochemical research, pharmaceutical development, and clinical diagnostics, particularly in studies of cell metabolism, cancer research, and enzyme kinetics.

Application

• Biochemical Research & Assay Development: Used as a key reagent in enzymatic assays to study polyamine metabolism, enzyme inhibition, and kinetic parameters.
• Pharmaceutical Screening: Employed in high-throughput screening (HTS) platforms to identify and characterize potential inhibitors targeting polyamine biosynthesis for therapeutic applications.
• Diagnostic Kit Manufacturing: Serves as a critical component in diagnostic kits for measuring ornithine decarboxylase activity in clinical samples, relevant to certain metabolic and neoplastic conditions.
• Academic & Industrial R&D: Utilized in life science laboratories for fundamental research into cell cycle regulation, signal transduction, and plant physiology.
• Enzyme Engineering Studies: Acts as a model protein for studies in protein stability, catalysis, and the development of immobilized enzyme systems.

Basic Information

Product Name	L-Ornithine Decarboxylase From Escherichia Coli
CAS No.	9024-60-6
Molecular Formula	N/A (Protein)
Molecular Weight	~80,000 Da (Tetramer, subunit ~20,000 Da)
Synonyms	Ornithine Decarboxylase; ODC; L-Ornithine Carboxy-Lyase; EC 4.1.1.17; Escherichia coli ODC; Putrescine Synthase; L-Ornithine Decarboxylase (E. coli); Ornithine Decarboxylase (Escherichia coli)
EINECS	Contact for details

Quality Control

Our L-Ornithine Decarboxylase is produced and tested under stringent quality management systems. Each lot undergoes comprehensive analysis to ensure high specific activity, purity, and functional consistency. Certificates of Analysis (COA) detailing assay results, purity by SDS-PAGE, and specific activity (U/mg protein) are provided. We adhere to relevant guidelines for research-grade enzymes to guarantee reliable and reproducible performance in your applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation. Aliquot reconstituted enzyme to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Identification (Activity)	Catalyzes decarboxylation of L-ornithine
Specific Activity	≥ [Value] units/mg protein
Purity (SDS-PAGE)	≥ 90%
Protein Content (Bradford)	Reported on COA
Stabilizers / Buffer	Potassium phosphate, DTT, Pyridoxal phosphate
pH (in solution)	7.0 - 7.5

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.