Description

Native Cystathionine-β-Synthase CAS NO 9023-99-8 is a purified, high-activity enzyme critical for the transsulfuration pathway in homocysteine metabolism. This product is essential for biochemical research, diagnostic assay development, and the study of metabolic disorders such as homocystinuria. It is primarily utilized by life science researchers, diagnostic manufacturers, and pharmaceutical companies engaged in enzyme kinetics studies, metabolic pathway analysis, and therapeutic target validation.

Application

• Biochemical Research & Enzyme Kinetics: Used as a key reagent for studying the catalytic mechanism, substrate specificity, and inhibition of the transsulfuration pathway.
• Diagnostic Kit Manufacturing: Serves as a critical component in enzymatic assays for the quantitative determination of homocysteine and related metabolites in clinical samples.
• Metabolic Disorder Studies: Essential for in vitro modeling and research into homocystinuria and other disorders linked to CBS enzyme deficiency or dysfunction.
• Pharmaceutical Screening: Employed in high-throughput screening platforms to identify and characterize potential modulators or therapeutic agents targeting CBS activity.
• Academic & Educational Use: Provides a standard enzyme for university laboratories and courses focused on advanced enzymology and metabolic biochemistry.
• Quality Control Reference: Acts as a reference standard for the calibration and validation of diagnostic methods and research protocols.

Basic Information

Product Name	Native Cystathionine-β-Synthase
CAS No.	9023-99-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Cystathionine β-synthase; CBS; Cystathionine β-synthase; Cystathionine-β-synthase; Serine sulfhydrase; L-Serine hydro-lyase (adding homocysteine); EC 4.2.1.22
EINECS	Contact for details

Quality Control

Our Native Cystathionine-β-Synthase is produced and tested under stringent quality management systems. Each lot is characterized for specific activity, purity, and stability to ensure performance consistency for critical research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing assay results, purity profiles, and storage stability data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive). Avoid repeated freeze-thaw cycles. For optimal preservation, aliquot the product upon receipt under controlled, low-humidity conditions.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Identification (Activity)	Conforms
Specific Activity	≥ [Value] units/mg protein
Purity (SDS-PAGE)	≥ 90%
Protein Content	Determined by Bradford / UV
pH	7.0 - 8.0 (in storage buffer)
Endotoxin Level	< 1.0 EU/mg (if applicable)
Storage Buffer	Tris-HCl, Glycerol, DTT (typical)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.