Description

Urocanate Hydratase is a crucial enzyme that catalyzes the hydration of urocanate to imidazolone propionate, a key step in the histidine degradation pathway. This biocatalyst is essential for research and industrial processes requiring precise metabolic pathway manipulation or enzymatic conversion. It is primarily utilized by biochemical researchers, pharmaceutical developers, and manufacturers in the life sciences sector for applications ranging from metabolic studies to the synthesis of fine chemicals and diagnostic reagents.

Application

• Biochemical Research: Used as a critical tool for studying the histidine catabolic pathway, enzyme kinetics, and metabolic disorders.
• Pharmaceutical Development: Employed in the synthesis of intermediates for drug candidates and in vitro metabolic modeling.
• Diagnostic Reagent Manufacturing: Serves as a key component in enzymatic assay kits for clinical diagnostics and research.
• Enzyme Engineering Studies: Provides a model enzyme for protein engineering, stability, and activity optimization research.
• Industrial Biocatalysis: Potential use in biocatalytic processes for the production of chiral compounds or specialty chemicals.

Basic Information

Product Name	Urocanate Hydratase
CAS No.	9014-58-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Urocanase; Urocanate Hydratase; Imidazolone Propionate Hydrolase; Histidine Ammonia-Lyase (Urocanate Hydratizing); Urocanate Hydratase Enzyme; EC 4.2.1.49; Histidase (in some contexts)
EINECS	Contact for details

Quality Control

Our Urocanate Hydratase is produced and tested under stringent quality management protocols to ensure high purity, specific activity, and batch-to-batch consistency. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as activity units, protein content, and purity. We adhere to relevant quality standards suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent moisture absorption, which can affect enzymatic activity. For short-term use, aliquoting is recommended to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Identification (Activity)	Conforms
Specific Activity	≥ [Value] units/mg protein
Protein Content (Biuret)	≥ [Value] %
Purity (SDS-PAGE)	≥ [Value] %
pH (in solution)	6.0 - 8.0
Endotoxin (LAL)	< 1.0 EU/μg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.