Description

C-Mpl Ligand is a critical cytokine protein that plays a fundamental role in the regulation of megakaryocyte development and platelet production. This compound is essential for research and development in hematology and oncology, particularly in studies related to thrombopoiesis and related disorders. It is primarily utilized by biotechnology firms, academic research institutions, and pharmaceutical companies engaged in the development of novel therapeutics for blood-related conditions.

Application

• Hematology Research: Fundamental studies on megakaryocyte differentiation, platelet biogenesis, and the mechanisms of thrombopoietin (TPO) signaling.
• Oncology & Cancer Therapy Development: Investigation of its role in supporting hematopoietic recovery following chemotherapy-induced myelosuppression.
• Cell Culture & Bioprocessing: Used as a growth factor component in ex vivo expansion protocols for hematopoietic stem cells and progenitor cells.
• Therapeutic Protein & Drug Discovery: Serves as a key reagent and target in the screening and development of TPO mimetics and related agonist/antagonist compounds.
• Diagnostic Assay Development: Employed as a standard or calibrator in immunoassays designed to measure TPO levels in clinical or research samples.
• Biochemical & Mechanistic Studies: Protein-protein interaction studies to elucidate the structure and function of the TPO receptor (c-Mpl) complex.

Basic Information

Product Name	C-Mpl Ligand
CAS No.	9014-42-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Thrombopoietin; TPO; Megakaryocyte Growth and Development Factor (MGDF); c-mpl ligand; ML; Myeloproliferative leukemia virus oncogene ligand; TPOR ligand
EINECS	Contact for details

Quality Control

Our C-Mpl Ligand is produced and tested under stringent quality management systems to ensure batch-to-batch consistency and biological activity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as purity, endotoxin levels, and biological potency. We adhere to relevant guidelines for research-grade biological materials to support your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Avoid repeated freeze-thaw cycles. For optimal preservation, aliquot into single-use quantities upon receipt.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (SDS-PAGE)	Complies
Purity (HPLC)	≥ 95%
Endotoxin Level (LAL)	< 1.0 EU/µg
Biological Activity (Cell-based assay)	Reported on COA
Protein Content	Reported on COA
Solubility	Clear, colorless solution at specified concentration

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.