Description

Coagulation Factor XIII, Human is a vital plasma protein that plays a crucial role in the final stage of the blood coagulation cascade by cross-linking fibrin to form a stable clot. This high-purity biological product is essential for research, diagnostic development, and therapeutic applications. It is primarily utilized by pharmaceutical manufacturers, clinical research organizations, and diagnostic kit producers focused on hemostasis and thrombosis.

Application

• Therapeutic Agent Development: As a critical component in the formulation of fibrin sealants and hemostatic products for surgical and trauma care.
• Clinical Diagnostics: Used as a reference standard and key reagent in coagulation factor assays and kits to diagnose Factor XIII deficiency.
• Biomedical Research: Fundamental for in vitro studies investigating the biochemistry of blood coagulation, fibrinolysis, and wound healing processes.
• Quality Control & Calibration: Serves as a calibrator and control material in laboratory settings to ensure the accuracy of hemostasis testing equipment.
• Enzyme Substrate Studies: Employed in enzymatic activity assays to study Factor XIII activation and its transglutaminase function.

Basic Information

Product Name	Coagulation Factor XIII, Human
CAS No.	9013-56-3
Molecular Formula	Contact for details
Molecular Weight	~320,000 Da (Tetrameric A2B2 complex)
Synonyms	Fibrin Stabilizing Factor; FSF; Plasma Transglutaminase; Laki-Lorand Factor; Fibrinoligase; Blood Coagulation Factor XIII; Activated Factor XIII; FXIII; EC 2.3.2.13
EINECS	Contact for details

Quality Control

Our Coagulation Factor XIII, Human is manufactured and tested under stringent quality systems. Each lot is characterized for identity, purity, and functional activity to ensure it meets the rigorous demands of research and diagnostic applications. Certificates of Analysis (COA) detailing specific purity, activity (IU/mg), and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Avoid repeated freeze-thaw cycles. Handle as a biological product under appropriate conditions.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Identification (Functional)	Positive for transglutaminase activity
Purity (SDS-PAGE)	≥ 90% (A2B2 complex)
Specific Activity	≥ XX IU/mg protein (Contact for lot-specific data)
pH (in solution)	6.5 - 7.5
Endotoxin	< 1.0 EU/mg
Solubility	Soluble in buffered saline or appropriate aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.