Description

Prothrombin Complex Concentrates CAS NO 37224-63-8 are a critical pharmaceutical preparation derived from human plasma, containing the vitamin K-dependent clotting factors II, VII, IX, and X. This product is essential for the rapid reversal of serious bleeding in patients with acquired or congenital deficiencies of these coagulation factors. It is primarily required by hospitals, blood banks, and pharmaceutical manufacturers specializing in hemostatic therapies and critical care medicine.

Application

• Treatment of Bleeding Episodes: Urgent reversal of bleeding in patients with acquired deficiency of vitamin K-dependent clotting factors due to warfarin or other anticoagulant therapy.
• Surgical Prophylaxis: Management of perioperative bleeding risk in patients with congenital deficiencies such as Hemophilia B (Factor IX deficiency) with inhibitors.
• Hemostatic Control: Critical care management of major bleeding events in trauma, cardiac surgery, or liver disease where multiple coagulation factor deficiencies are present.
• Pharmaceutical Manufacturing: As a key active pharmaceutical ingredient (API) or intermediate in the production of specialized hemostatic drugs and biologics.
• Clinical Research: Used in laboratory and clinical studies focused on coagulation disorders, thrombosis, and the development of new therapeutic protocols.

Basic Information

Product Name	Prothrombin Complex Concentrates
CAS No.	37224-63-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PCC; Prothrombin Complex; Coagulation Factor Complex; Factor IX Complex; Konyne; Proplex; Beriplex; Octaplex; Cofact; Prothrombinex; Vitamin K-Dependent Clotting Factor Concentrate; Anti-Inhibitor Coagulant Complex (some preparations)
EINECS	Contact for details

Quality Control

Our Prothrombin Complex Concentrates are manufactured under strict pharmaceutical guidelines. Each batch undergoes rigorous quality testing to ensure compliance with relevant pharmacopoeial standards (e.g., Ph. Eur., USP) and regulatory requirements for plasma-derived products. This includes comprehensive testing for potency, purity, sterility, and viral safety. Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at the recommended temperature, typically between 2°C and 8°C (refrigerated) unless otherwise specified for a specific formulation. Do not freeze. Keep out of reach of children.

Specification

Item	Specification
Description	Sterile, freeze-dried powder or solution
Identification (Immunological)	Complies
Assay (Factor IX Activity)	As per label claim
Assay (Factors II, VII, X)	Specified ranges
pH	6.5 - 7.5 (for solution)
Sterility	Sterile
Bacterial Endotoxins	< Specified limit
Total Protein	Specified limit
Moisture (for lyophilized)	< 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.