Description

Protamine Z2 is a highly purified, low molecular weight polypeptide derived from salmon sperm, primarily known for its potent heparin-neutralizing activity. This makes it a critical pharmaceutical intermediate for the development of life-saving antidotes and controlled-release drug delivery systems. It is essential for manufacturers in the biopharmaceutical and advanced medical research sectors who require a reliable, high-purity source for heparin reversal agents and innovative therapeutic formulations. Protamine Z2 CAS NO 105005-94-5 represents a key building block for next-generation medical applications.

Application

• Heparin Antidote Production: Primary active pharmaceutical ingredient (API) in formulations used to reverse the anticoagulant effects of heparin during surgical procedures.
• Drug Delivery Systems: Utilized as a cationic polymer to form complexes with anionic drugs (e.g., insulin, nucleic acids) for sustained or targeted release.
• Biopharmaceutical Research: Serves as a model cationic peptide in studies of protein-protein interactions, cell penetration, and gene transfection.
• Diagnostic Reagent Component: Used in certain in-vitro diagnostic kits and assays that require heparin neutralization steps.
• Vaccine Adjuvant Development: Investigated for its potential to enhance immune responses in novel vaccine formulations.
• Tissue Engineering: Explored as a biocompatible coating or component in scaffolds to modulate cell growth and differentiation.

Basic Information

Product Name	Protamine Z2
CAS No.	105005-94-5
Molecular Formula	Contact for details
Molecular Weight	~4000 - 6000 Da (Approx.)
Synonyms	Protamine Sulfate Fraction Z2; Protamine Z-2; Salmon Protamine Z2; Clupeine Z2; Heparin Antagonist Z2; Low Molecular Weight Protamine (LMWP) Z2; Protamine Component Z2
EINECS	Contact for details

Quality Control

Our Protamine Z2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, potency, and safety, suitable for pharmaceutical development. A detailed Certificate of Analysis (COA) documenting tests such as assay (HPLC), peptide content, endotoxin levels, and residual solvents is provided with every shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and potency. For long-term storage, consider conditions of 2-8°C.

Specification

Item	Specification
Appearance	White or almost white powder
Identification (IR)	Conforms to standard
Assay (HPLC)	≥ 95.0% (on anhydrous basis)
Water Content (KF)	≤ 8.0 %
Peptide Content (Ninhydrin)	≥ 80.0 %
Endotoxins (LAL)	< 10.0 EU/mg
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.