Description

Coagulation Factor XI, Human is a high-purity plasma-derived glycoprotein essential for the intrinsic pathway of blood coagulation. This critical hemostatic agent is vital for research, diagnostic, and therapeutic applications where precise control of the clotting cascade is required. It is primarily utilized by biopharmaceutical manufacturers, clinical diagnostic laboratories, and advanced life science research institutions developing and producing coagulation factor concentrates, calibrators, controls, and research reagents.

Application

• Therapeutic Protein Manufacturing: As an active pharmaceutical ingredient (API) in the production of coagulation factor XI concentrates for the treatment of congenital Factor XI deficiency (Hemophilia C).
• In-Vitro Diagnostic (IVD) Reagents: As a calibrated standard or quality control material in clinical coagulation analyzers to test for Factor XI activity and diagnose clotting disorders.
• Biomedical Research: For studying the biochemistry of the contact activation pathway, thrombosis, hemostasis, and the development of novel antithrombotic therapies.
• Assay Development: As a key component in developing functional chromogenic or clotting assays to measure Factor XI levels and inhibitor antibodies.
• Cell Culture & Biochemistry: Used in specialized cell culture media and biochemical studies requiring defined plasma protein components.

Basic Information

Product Name	Coagulation Factor XI, Human
CAS No.	9013-55-2
Molecular Formula	Contact for details
Molecular Weight	~160,000 Da (Heterodimer)
Synonyms	Factor XI, Human; Plasma Thromboplastin Antecedent (PTA); F11; FXI; Coagulation Factor F11; Antihemophilic Factor C; Hemophilia C Factor; EC 3.4.21.27
EINECS	Contact for details

Quality Control

Our Coagulation Factor XI, Human is manufactured and tested under strict quality systems. Each lot is characterized for identity, purity, and functional activity to ensure it meets the rigorous standards required for pharmaceutical and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing specifications such as specific activity, purity by SDS-PAGE, and absence of relevant impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C or below. Avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Identification (Immunological)	Complies
Purity (SDS-PAGE)	≥ 95%
Specific Activity	≥ [Value] U/mg protein
pH	6.5 - 7.5 (in solution)
Endotoxin	< 1.0 EU/mg
Sterility (where applicable)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.