Description

Dopamine β-Hydroxylase (DBH) is a copper-containing monooxygenase enzyme that catalyzes the conversion of dopamine to norepinephrine. This enzymatic activity is critical for the biosynthesis of catecholamine neurotransmitters, making it a vital reagent in biochemical research and pharmaceutical development. It is primarily utilized by researchers and manufacturers in the fields of neuroscience, pharmacology, and diagnostic assay development.

Application

• Biochemical Research: Used as a key enzyme in studies of catecholamine biosynthesis, neurotransmitter regulation, and enzymatic kinetics.
• Pharmaceutical Development: Employed in screening assays for drug discovery targeting neurological disorders, hypertension, and cardiovascular diseases.
• Diagnostic Reagent Manufacturing: Serves as a critical component in the production of clinical diagnostic kits for measuring catecholamine levels.
• Enzyme Activity Studies: Applied in vitro to investigate enzyme inhibitors, activators, and the effects of genetic polymorphisms on DBH function.
• Academic & Industrial Laboratories: Essential for standardizing enzymatic assays and producing reference materials for quality control.

Basic Information

Product Name	Dopamine β-Hydroxylase
CAS No.	9013-38-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Dopamine β-Hydroxylase; DBH; Dopamine β-Monooxygenase; 3,4-Dihydroxyphenylethylamine, ascorbate:oxygen oxidoreductase (β-hydroxylating); Dopamine Beta Monooxygenase; Noradrenaline Synthetase
EINECS	Contact for details

Quality Control

Our Dopamine β-Hydroxylase is produced and tested under stringent quality management systems to ensure batch-to-batch consistency and high enzymatic activity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, specific activity, and stability data. We adhere to relevant guidelines for research-grade biochemicals to support reproducible scientific results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent moisture absorption. For short-term use, aliquoting is recommended to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Identification (IR / Activity)	Conforms
Specific Activity	Contact for details
Protein Content (Biuret)	Contact for details
Purity (SDS-PAGE)	> 90%
Stability	Stable under recommended storage conditions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.