Description

Corticosteroid-Binding Globulin (CBG) is a high-purity plasma glycoprotein that specifically binds and transports glucocorticoids and progesterone in the bloodstream. This compound is critical for regulating the bioavailability, distribution, and metabolic clearance of endogenous steroid hormones. It is an essential biochemical reagent for researchers and manufacturers in pharmaceutical development, endocrinology research, clinical diagnostics, and biotechnology, facilitating studies on hormone transport, metabolism, and receptor interactions.

Application

• Biochemical Research & Assay Development: Used as a key component in competitive binding assays (e.g., radioimmunoassays) to measure free and bound cortisol levels.
• Pharmaceutical R&D: Employed in drug discovery to study drug-protein interactions, pharmacokinetics, and the development of novel steroid-based therapeutics.
• Clinical Diagnostics: Serves as a standard or critical reagent in diagnostic kits for assessing adrenal function and hormonal disorders.
• Endocrinology Studies: Fundamental for in vitro and ex vivo research on steroid hormone transport, metabolism, and physiological regulation.
• Biotechnology Production: Used in downstream purification processes and quality control for related biopharmaceutical products.
• Reference Standard: Acts as a high-purity calibrant or control material in analytical laboratories for method validation.

Basic Information

Product Name	Corticosteroid-Binding Globulin
CAS No.	9013-32-5
Molecular Formula	Contact for details
Molecular Weight	~52 kDa (Glycoprotein)
Synonyms	Transcortin; CBG; Serpin A6; SERPINA6; Corticosteroid-Binding Globulin, Human; Cortisol-Binding Globulin; Cortisol Binding Globulin; CBG Protein; α-1-Antitrypsin-like Protein
EINECS	Contact for details

Quality Control

Our Corticosteroid-Binding Globulin is produced and tested under stringent quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and functional activity. A Certificate of Analysis (COA) detailing specifications such as purity (by SDS-PAGE/HPLC), biological activity (binding capacity), and endotoxin levels is provided with every shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Identification (Immunological)	Complies
Purity (SDS-PAGE)	≥ 95%
Protein Content (Biuret/BCA)	≥ 90%
Biological Activity (Binding Assay)	Contact for details
Endotoxin (LAL)	< 1.0 EU/mg
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.