Description

Penicillinase is a specific β-lactamase enzyme that catalyzes the hydrolysis of the β-lactam ring in penicillin antibiotics, rendering them inactive. This property is critically important for analytical and diagnostic applications where the selective inactivation of penicillin is required. It is an essential reagent for pharmaceutical quality control laboratories, diagnostic kit manufacturers, and research institutions working in antibiotic resistance and microbiology.

Application

• Pharmaceutical Quality Control: Used in sterility testing and antibiotic residue detection to neutralize penicillin, ensuring accurate microbiological assay results.
• Diagnostic Reagents: A key component in diagnostic kits and culture media for the specific identification of penicillin-resistant bacterial strains.
• Research & Development: Employed in biochemical research to study β-lactamase enzyme kinetics, mechanisms of antibiotic resistance, and drug development.
• Food Safety Testing: Applied in methods for the detection and confirmation of penicillin residues in milk, meat, and other food products.
• Clinical Microbiology: Utilized in hospital laboratories for phenotypic confirmation of β-lactamase production in clinical bacterial isolates.
• Enzyme Preparation: Serves as a reference standard and active ingredient in the formulation of specialized enzymatic preparations.

Basic Information

Product Name	Penicillinase
CAS No.	9012-26-4
Molecular Formula	N/A (Enzyme)
Molecular Weight	~29 kDa (Approximate)
Synonyms	β-lactamase I; Penicillin β-lactamase; Penicillin amido-β-lactamhydrolase; Penase; Neutrapen; Benzylpenicillinase; EC 3.5.2.6
EINECS	Contact for details

Quality Control

Our Penicillinase is produced and tested under strict quality management systems. Each batch is characterized for its specific activity and purity to ensure consistent performance for critical applications. A comprehensive Certificate of Analysis (COA) detailing activity units, protein content, and purity is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term stability, avoid repeated freeze-thaw cycles and store desiccated.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Identification (Activity)	Conforms
Specific Activity	> 1,500 units/mg protein
Protein Content (Biuret)	Contact for details
Purity (SDS-PAGE)	> 90%
pH (in solution)	6.0 - 7.5
Endotoxin	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.