Description

Catechol o-Methyltransferase CAS NO 9012-25-3 is a crucial enzyme that catalyzes the transfer of a methyl group from S-adenosyl methionine to catechol substrates, including neurotransmitters like dopamine and norepinephrine. This biochemical activity makes it an essential reagent for research in neuropharmacology, metabolic studies, and drug discovery. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and diagnostic manufacturers focused on understanding neurological disorders, Parkinson's disease, and catecholamine metabolism.

Application

• Enzymatic Research & Biochemical Assays: Used as a standard enzyme in kinetic studies and to develop in-vitro assays for measuring enzyme activity and inhibition.
• Neuropharmacology & Drug Discovery: Critical for screening and evaluating potential inhibitors as therapeutic agents for conditions like Parkinson's disease.
• Metabolic Pathway Analysis: Employed in studies to understand the methylation pathways of catecholamines and other phenolic compounds.
• Diagnostic Kit Manufacturing: Serves as a key component in the production of diagnostic kits for enzymatic activity tests related to neurological health.
• Academic & Educational Use: Supplied to universities and teaching hospitals for advanced biochemistry and molecular biology coursework and research projects.
• Biocatalyst Development: Investigated for potential use in synthetic chemistry for selective methylation reactions under mild conditions.

Basic Information

Product Name	Catechol o-Methyltransferase
CAS No.	9012-25-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	COMT; Catechol Methyltransferase; Catecholamine o-Methyltransferase; S-adenosyl-L-methionine:catechol O-methyltransferase; EC 2.1.1.6; 3,4-Dihydroxybenzene methyltransferase
EINECS	Contact for details

Quality Control

Our Catechol o-Methyltransferase is produced and tested under stringent quality management systems. Each lot undergoes rigorous analysis to ensure high specific activity, purity, and stability, meeting the exacting standards required for research and diagnostic applications. Certificates of Analysis (COA) detailing specific activity, protein content, and purity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Avoid repeated freeze-thaw cycles to maintain optimal enzymatic activity.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Specific Activity	Contact for details
Protein Content (Biuret)	≥ 90%
Purity (SDS-PAGE)	Single major band
Stabilizers	May contain buffer salts (e.g., Tris, phosphate) and glycerol
Solubility	Soluble in aqueous buffers
pH (in solution)	7.0 - 8.0

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.