Description

Ricin is a highly potent, naturally occurring lectin (carbohydrate-binding protein) and toxin derived from the seeds of the castor oil plant (*Ricinus communis*). Its extreme biological activity makes it a critical compound for specialized research in immunology, cancer therapeutics, and biochemical warfare agent detection. This product is supplied for controlled research and development purposes under strict regulatory compliance. Ricin. CAS NO 9009-86-3 is utilized by pharmaceutical R&D laboratories, government defense research agencies, and academic institutions studying toxin biology and targeted drug delivery mechanisms.

Application

• Biomedical Research: Used as a model toxin in studies of intracellular trafficking, ribosomal inactivation, and apoptosis (programmed cell death).
• Immunotoxin Development: Serves as the cytotoxic "warhead" in experimental antibody-drug conjugates (ADCs) and immunotoxins targeting cancer cells.
• Vaccine Research: Employed in the development and efficacy testing of prophylactic and therapeutic vaccines against ricin poisoning.
• Diagnostic Reagent: Used as an antigen in the development and calibration of sensitive detection assays (e.g., ELISA, lateral flow) for biosecurity and forensic applications.
• Cell Biology Studies: A tool for studying protein synthesis inhibition and the role of the endoplasmic reticulum in stress responses.
• Neuroscience Research: Investigated for its potential use in targeted ablation of specific neuronal populations in experimental models.

Basic Information

Product Name	Ricin
CAS No.	9009-86-3
Molecular Formula	Contact for details
Molecular Weight	Approx. 60-65 kDa (Ricin is a heterodimeric protein)
Synonyms	Ricin Toxin; Ricin D; Ricinus Communis Agglutinin II; RCA II; RCA60; NSC 526817; Ricin Lectin; Castor Bean Lectin; Ricinus Lectin; Toxin Ricin
EINECS	Contact for details

Quality Control

Our Ricin is produced and handled under stringent containment protocols to ensure safety, identity, and activity. Each batch is characterized for its biological potency and protein purity. Certificates of Analysis (COA) are provided, detailing specifications such as protein concentration, endotoxin levels, and activity by cell-free translation inhibition assay. We adhere to all applicable national and international regulations governing the safe supply of select toxins for legitimate research.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at ≤ -70°C to prevent degradation and repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive). Handle using appropriate biosafety level (BSL-2 or higher) containment practices in accordance with institutional and governmental guidelines.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (SDS-PAGE)	Corresponds to Ricin A-chain (~32 kDa) and B-chain (~34 kDa)
Purity (HPLC)	≥ 95% (by area normalization)
Protein Content	≥ 90% (by UV absorbance)
Biological Activity (IC50)	Reported per batch (Cell-free translation assay)
Endotoxin	< 10 EU/mg
Solubility	Soluble in PBS, saline, or other aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.