Description

Protamine Sulfate is a purified mixture of simple cationic proteins derived from the sperm of salmon and certain other fish species. This compound is critically important as a heparin antagonist, effectively reversing the anticoagulant effects of heparin and low molecular weight heparins. It is an essential pharmaceutical agent used in surgical and clinical settings to manage and control bleeding. Industries that rely on this product include pharmaceutical manufacturing, biotechnology research, and clinical diagnostics.

Application

• Heparin Neutralization: Primary use as a reversal agent for heparin and low molecular weight heparin (LMWH) anticoagulation following cardiovascular surgery, dialysis, and other medical procedures.
• Pharmaceutical Formulation: Used as an excipient or active pharmaceutical ingredient (API) in injectable drug products designed to control bleeding.
• Biotechnology & Research: Employed in laboratory research for studying protein-protein interactions, nucleic acid precipitation, and cell biology due to its strong positive charge.
• Diagnostic Kits: A key component in certain in-vitro diagnostic (IVD) test kits and assays that require heparin neutralization for accurate results.
• Drug Delivery Systems: Investigated for use in forming complexes with nucleic acids (like DNA/RNA) for potential gene delivery and vaccine development applications.

Basic Information

Product Name	Protamine Sulfate
CAS No.	9009-65-8
Molecular Formula	Mixture of proteins
Molecular Weight	~5,000 - 10,000 Da (Average)
Synonyms	Protamine Sulphate; Salmine Sulfate; Clupeine Sulfate; Heparin Antagonist; 1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-; Protein from Salmon Sperm; Protamine, sulfate
EINECS	Contact for details

Quality Control

Our Protamine Sulfate is manufactured and tested to meet stringent quality standards suitable for pharmaceutical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) that confirms identity, purity, potency, and safety. We adhere to current Good Manufacturing Practices (cGMP) and can supply material compliant with relevant pharmacopeial monographs (e.g., USP, EP) upon request. Our rigorous quality testing ensures reliable performance and supply chain consistency for our global B2B partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent absorption of atmospheric moisture. For long-term stability, consider storage under inert atmosphere.

Specification

Item	Specification
Appearance	White or off-white powder
Identification (IR)	Conforms
Assay (on dried basis)	Not less than 90.0%
pH (1% solution)	6.0 - 7.0
Loss on Drying	Not more than 5.0%
Residue on Ignition	Not more than 1.0%
Heparin Neutralizing Potency	Meets required activity
Bacterial Endotoxins	< 5.0 IU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.