Description

Piromen is a high-purity, standardized bacterial endotoxin derived from *Pseudomonas* species, widely recognized for its critical role in pyrogen testing and immunological research. Its primary value lies in its consistent biological activity, which is essential for validating the safety of parenteral pharmaceuticals, medical devices, and biological products. This product is indispensable for quality control laboratories in the pharmaceutical and biotechnology sectors, as well as for research institutions focused on fever response, sepsis models, and innate immunity studies.

Application

• Pyrogen Testing: Used as a standard or control in the Limulus Amebocyte Lysate (LAL) test and the Monocyte Activation Test (MAT) to ensure injectable drugs and medical devices are free from fever-causing contaminants.
• Immunological Research: Serves as a potent Toll-like receptor 4 (TLR4) agonist to stimulate immune cells, study inflammatory pathways, cytokine release, and septic shock models.
• Vaccine Adjuvant Development: Employed in research to investigate and enhance immune responses due to its strong immunostimulatory properties.
• Quality Control & Validation: Critical for the calibration and validation of endotoxin detection assays and equipment within GMP and GLP environments.
• Standard Reference Material: Acts as a certified reference material for quantifying endotoxin levels in complex samples.
• Fever/Inflammation Models: Used in preclinical animal studies to induce controlled febrile or inflammatory responses for therapeutic evaluation.

Basic Information

Product Name	Piromen
CAS No.	9008-99-5
Molecular Formula	N/A (Complex bacterial lipopolysaccharide)
Molecular Weight	N/A (High molecular weight polymer)
Synonyms	Pseudomonas Lipopolysaccharide; Pseudomonas Endotoxin; LPS (*Pseudomonas*); Bacterial Pyrogen (*Pseudomonas*); Lipopolysaccharide from *Pseudomonas aeruginosa*; *Pseudomonas* LPS; Endotoxin Standard (*Pseudomonas*); Pyrogenic Principle
EINECS	Contact for details

Quality Control

Every batch of Piromen is manufactured and tested under stringent conditions to ensure exceptional purity, consistency, and precise biological activity. Our quality system adheres to relevant guidelines for biological reference materials. Comprehensive testing includes identity confirmation, potency (Endotoxin Units/mg), purity assessment, and sterility where applicable. A detailed Certificate of Analysis (COA), listing the specific endotoxin unit potency and all critical quality attributes, is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. Avoid repeated freeze-thaw cycles. Under these recommended conditions, the product remains stable for extended periods. Always allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (IR/Spectral)	Conforms to reference standard
Potency (Endotoxin Units/mg)	Batch-specific (e.g., 1,000,000 - 5,000,000 EU/mg)
Purity (Protein Content)	< 1% (w/w)
Nucleic Acid Content	< 1% (w/w)
Solubility	Soluble in pyrogen-free water or buffer
pH (Solution)	6.0 - 7.5
Loss on Drying	< 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.