Description

Intrinsic Factor is a glycoprotein essential for the absorption of vitamin B12 (cobalamin) in the small intestine. This compound is critical for research and development in the fields of hematology, nutrition, and gastroenterology. It is primarily utilized by manufacturers of diagnostic kits, pharmaceutical companies developing B12-related therapies, and research institutions studying pernicious anemia and malabsorption syndromes.

Application

• Diagnostic Reagent Manufacturing: A key component in immunoassay kits for the quantitative and qualitative determination of vitamin B12 levels and related antibodies in serum.
• Pharmaceutical Research: Used in the development and testing of formulations and delivery systems aimed at treating vitamin B12 deficiency and pernicious anemia.
• Biochemical Research: Serves as a vital reagent in studies investigating the mechanism of cobalamin absorption, transport, and cellular uptake.
• Nutraceutical & Food Science: Employed in bioavailability studies to assess the efficiency of vitamin B12 fortification in functional foods and supplements.
• Quality Control & Standardization: Acts as a reference standard for calibrating assays and ensuring the accuracy of diagnostic and research measurements.

Basic Information

Product Name	Intrinsic Factor
CAS No.	9008-12-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Gastric Intrinsic Factor; Castle's Intrinsic Factor; IF; Cobalamin-binding Intrinsic Factor; Vitamin B12-binding Protein; GIF; Intrinsic Factor of Castle; EINECS 232-710-1

Quality Control

Our Intrinsic Factor is produced and tested under a rigorous quality management system. Each batch undergoes comprehensive analysis to ensure identity, purity, and biological activity, meeting the stringent requirements for research and in-vitro diagnostic use. Certificates of Analysis (COA) detailing purity, activity, and test methods are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Avoid repeated freeze-thaw cycles. Handle under controlled conditions to maintain activity.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Immunological)	Conforms
Purity (SDS-PAGE)	≥ 90%
Biological Activity	Conforms to reference standard
Protein Content (Biuret)	≥ 90% of dry weight
Solubility	Soluble in aqueous buffers
Endotoxin	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.