Description

C-Reactive Protein, Human is a highly purified, acute-phase plasma protein that serves as a critical biomarker for systemic inflammation and tissue damage. Its primary commercial value lies in its essential role as a key reagent and calibrator in the manufacturing of in-vitro diagnostic (IVD) kits and clinical research assays. This product is indispensable for pharmaceutical R&D, clinical laboratories, and biotechnology companies focused on immunology, cardiology, and autoimmune disease research, where precise quantification of inflammation is required.

Application

• IVD Kit Manufacturing: Primary calibrator and reference material for high-sensitivity (hs-CRP) and standard CRP immunoassay kits.
• Clinical Research & Biomarker Studies: Used as a standard in studies investigating the correlation between CRP levels and cardiovascular risk, sepsis, rheumatoid arthritis, and other inflammatory conditions.
• Antibody Production & Validation: Serves as a critical antigen for the generation, purification, and specificity testing of monoclonal and polyclonal anti-CRP antibodies.
• Quality Control in Biopharma: Employed as a process control and standard in the quality control of therapeutic proteins and plasma-derived products.
• Academic & Pharmaceutical R&D: Fundamental reagent for studying the innate immune response, complement activation, and the development of novel anti-inflammatory therapeutics.
• Assay Development: Essential for developing and optimizing new diagnostic platforms, including ELISA, chemiluminescence, lateral flow, and turbidimetric assays.

Basic Information

Product Name	C-Reactive Protein, Human
CAS No.	9007-41-4
Molecular Formula	CnHmNoOpSq (Protein)
Molecular Weight	~115 kDa (Pentameric form)
Synonyms	CRP; Human C-Reactive Protein; Pentraxin 1; PTX1; Acute-Phase Protein; CRP Human; Native Human CRP; hs-CRP Protein; C-Reactive Protein (Human); CRP Antigen
EINECS	Contact for details

Quality Control

Our C-Reactive Protein, Human is manufactured under strict quality systems to ensure batch-to-batch consistency and high biological activity. Each lot is rigorously tested to meet exacting standards for purity, identity, and functionality. A comprehensive Certificate of Analysis (COA) is provided, detailing specifications such as purity by SDS-PAGE, immunoreactivity, endotoxin levels, and functional activity in standard assays. Production adheres to relevant quality guidelines suitable for research and diagnostic manufacturing applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted protein aliquots should be stored at -70°C to -80°C and avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the vial is at room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder
Identification (Immunodiffusion/Western Blot)	Complies
Purity (SDS-PAGE, reduced & non-reduced)	> 95%
Assay (Immunoassay)	90% - 110% of stated concentration
Endotoxin	< 1.0 EU/μg
Solubility	Soluble in PBS or Tris buffer
Biological Activity	Calibrates against WHO/IFCC reference standard

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.