Description

Protamine Sulfate Grade III From Herring is a highly purified, low molecular weight protein derived from the sperm of herring, widely recognized for its strong cationic properties and ability to neutralize heparin. This specific Grade III classification indicates a high-purity material suitable for critical pharmaceutical and research applications where consistency and biological activity are paramount. It is an essential reagent for biochemists, pharmaceutical manufacturers, and clinical laboratories involved in heparin reversal, cell culture, and nucleic acid purification processes.

Application

• Heparin Neutralization: Primary use as a reversal agent for heparin anticoagulation in clinical settings and in vitro diagnostic assays.
• Pharmaceutical Manufacturing: Critical component in the production of slow-release insulin formulations (e.g., NPH insulin) and other sustained-release drug delivery systems.
• Biochemical Research: Used in molecular biology for precipitating nucleic acids and as a tool for studying protein-DNA/RNA interactions.
• Cell Culture & Tissue Engineering: Employed to form polyelectrolyte complexes for coating surfaces and creating scaffolds.
• Diagnostic Reagents: Integral part of test kits and controls for measuring heparin levels and coagulation parameters.
• Protein Purification: Aids in the purification processes of various anionic biomolecules.

Basic Information

Product Name	Protamine Sulfate Grade III From Herring
CAS No.	9007-31-2
Molecular Formula	Contact for details
Molecular Weight	~5,000 Da (Average)
Synonyms	Protamine Sulphate; Herring Protamine Sulfate; Clupeine Sulfate; Salmine Sulfate; Heparin Antagonist; 1,2,3-Propanetriol, homopolymer, sulfate; Protamine, sulfate
EINECS	Contact for details

Quality Control

Our Protamine Sulfate Grade III is manufactured and tested to meet exacting standards for pharmaceutical and research use. Each batch is subjected to a comprehensive battery of tests including identity, purity, potency, and biological activity. A Certificate of Analysis (COA) detailing specifications such as nitrogen content, potency (heparin neutralizing capacity), and limits for impurities is provided to ensure traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White or almost white powder
Identification (IR)	Conforms
pH (Solution)	6.0 - 7.5
Nitrogen Content (Dumas)	21.0% - 25.0%
Potency (Heparin Neutralization)	Not less than 100 USP units/mg
Loss on Drying	≤ 5.0%
Residue on Ignition (Sulfated Ash)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.