Description

Bence Jones Protein CAS NO 9006-99-9 is a monoclonal immunoglobulin light chain, typically a dimer, that is a critical biomarker for plasma cell dyscrasias such as multiple myeloma. Its primary value lies in its use as a reference standard and diagnostic reagent in clinical and research laboratories for the identification and quantification of these pathological proteins. This product is essential for biopharmaceutical companies, clinical diagnostic labs, and academic research institutions focused on hematology, immunology, and oncology.

Application

• Clinical Diagnostic Reagent: Used as a primary standard in immunofixation electrophoresis (IFE) and immunoelectrophoresis for the definitive diagnosis of monoclonal gammopathies.
• Biomarker Research: Serves as a critical reference material in studies investigating the pathogenesis, progression, and treatment monitoring of multiple myeloma and related disorders.
• Assay Development & Calibration: Essential for the development, validation, and routine calibration of immunoassays (e.g., ELISA, nephelometry) designed to detect free light chains in serum and urine.
• Quality Control in IVD Manufacturing: Employed as a quality control material in the production of in-vitro diagnostic (IVD) kits and reagents for hematological testing.
• Therapeutic Antibody Research: Used as a model protein in studies of protein aggregation, amyloid formation, and light chain-related renal diseases.
• Academic & Pharmaceutical R&D: A key tool for basic research into B-cell biology, immunoglobulin structure/function, and for screening potential therapeutic compounds.

Basic Information

Product Name	Bence Jones Protein
CAS No.	9006-99-9
Molecular Formula	N/A (Protein)
Molecular Weight	~22-24 kDa (monomer); ~44-48 kDa (dimer)
Synonyms	Bence-Jones Protein; Immunoglobulin Light Chain; Free Light Chain (FLC); Monoclonal Light Chain; BJP; Urinary Light Chain; Paraprotein; M-protein (light chain); Kappa or Lambda Light Chain Dimer
EINECS	Contact for details

Quality Control

Our Bence Jones Protein is produced and tested under stringent quality management systems. Each lot is characterized for identity, purity, and activity using advanced analytical techniques including electrophoresis, immunoassay, and chromatography. A comprehensive Certificate of Analysis (COA) detailing purity (typically >95% by HPLC), light chain type (kappa or lambda), and functional data is provided with every shipment to ensure it meets the exacting standards required for diagnostic and research applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Avoid repeated freeze-thaw cycles. Aliquot upon receipt for single-use to maintain optimal activity.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Immunological)	Reacts specifically with anti-human kappa or lambda light chain antiserum
Purity (SDS-PAGE)	≥ 95%
Purity (HPLC)	≥ 95%
Protein Content (Biuret)	≥ 90%
Light Chain Type	Kappa or Lambda (specified)
Solubility	Soluble in water or PBS
Biological Activity	Reactivity confirmed by immunofixation electrophoresis

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.