Description

Aprotinin is a broad-spectrum, naturally occurring polypeptide protease inhibitor derived from bovine lung tissue. It is a critical biochemical tool and active pharmaceutical ingredient valued for its potent ability to inhibit serine proteases like trypsin, plasmin, and kallikrein. This product is essential for researchers in biochemistry and pharmacology, as well as manufacturers in the pharmaceutical and diagnostic industries.

Application

• Pharmaceutical Manufacturing: Used as an active ingredient in anti-fibrinolytic and anti-inflammatory medications to reduce perioperative blood loss.
• Biochemical Research: Serves as a standard protease inhibitor in enzymatic studies, cell culture, and protein purification protocols to prevent protein degradation.
• Diagnostic Reagents: Incorporated into in-vitro diagnostic kits and assay systems to stabilize samples and control proteolytic activity.
• Tissue Culture & Cell Biology: Added to serum-free media and cell lysates to inhibit trypsin and other proteases, maintaining cell integrity and protein function.
• Food Science Research: Employed in experimental studies to control proteolysis in food matrices and investigate enzyme mechanisms.

Basic Information

Product Name	Aprotinin
CAS No.	9004-04-0
Molecular Formula	C284H432N84O79S7
Molecular Weight	Approx. 6511.5 g/mol
Synonyms	Bovine Pancreatic Trypsin Inhibitor (BPTI); Trypsin Inhibitor, Basic Pancreatic; Kunitz Pancreatic Trypsin Inhibitor; Antikrein; Contrical; Gordox; Trasylol; Zymofren
EINECS	Contact for details

Quality Control

Our Aprotinin is produced and tested under strict quality management systems. Each batch is analyzed to meet high-purity standards suitable for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, activity, and impurity profiles is provided with every shipment to ensure traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. The product is hygroscopic (moisture-sensitive); ensure the container is kept sealed in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White or almost white lyophilized powder
Identification (IR)	Conforms to standard
Assay (HPLC)	≥ 95.0% (on dried basis)
Specific Activity	≥ 3.0 USP U/mg (vs. Trypsin)
Loss on Drying	≤ 6.0 %
Residue on Ignition	≤ 1.0 %
Bacterial Endotoxins	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.