Description

Xanthine Oxidase CAS NO 9002-17-9 is a critical molybdoflavoprotein enzyme that catalyzes the oxidation of hypoxanthine to xanthine and xanthine to uric acid. This enzymatic activity is fundamental for purine metabolism and is extensively utilized in biochemical research, diagnostic applications, and pharmaceutical development. It is an essential reagent for researchers and manufacturers in the life sciences, clinical diagnostics, and nutraceutical industries.

Application

• Clinical Diagnostics: Key component in enzymatic assays for the quantitative determination of uric acid levels in blood and serum, aiding in the diagnosis and monitoring of gout, hyperuricemia, and renal disorders.
• Biochemical Research: Used as a model enzyme to study reactive oxygen species (ROS) generation, oxidative stress pathways, and the mechanisms of molybdenum-containing enzymes.
• Pharmaceutical Screening: Employed in high-throughput screening (HTS) assays to identify and evaluate potential inhibitors for the development of novel therapeutics targeting gout and cardiovascular diseases.
• Food & Beverage Analysis: Applied in enzymatic methods for the detection and quantification of purine content in foods and beverages, important for nutritional labeling and quality control.
• Enzyme Inhibition Studies: Serves as a standard for testing the efficacy of natural and synthetic xanthine oxidase inhibitors, such as allopurinol and febuxostat.

Basic Information

Item	Details
Product Name	Xanthine Oxidase
CAS No.	9002-17-9
Molecular Formula	N/A (Protein)
Molecular Weight	Approx. 300 kDa (Dimer)
Synonyms	Xanthine Oxidoreductase; XO; Xanthine:Oxygen Oxidoreductase; EC 1.17.3.2; Hypoxanthine Oxidase; Xanthine Dehydrogenase (oxidized form); Aldehyde Oxidase (related); Milk Xanthine Oxidase
EINECS	Contact for details

Quality Control

Our Xanthine Oxidase is produced and tested under stringent quality management systems. Each batch undergoes comprehensive analysis to ensure high specific activity, purity, and functional consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as activity units, protein content, and purity. We adhere to relevant quality guidelines suitable for research and in-vitro diagnostic use.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	Yellowish to brownish suspension or lyophilized powder
Specific Activity	≥ 0.4 - 1.5 units/mg protein (varies by grade)
Protein Content (Biuret)	Defined per batch (COA)
Activity (U/mL or U/mg)	Defined per batch (COA)
Purity (SDS-PAGE)	Major band at ~150 kDa (subunit)
Stabilizer / Buffer	Typically in phosphate or Tris buffer with stabilizers
pH	7.0 - 8.0

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.